F-Amidine (trifluoroacetate salt)

CAS NO.：877617-46-4
Empirical Formula: C16H20F4N4O4
Molecular Weight: 408.35
SAFETY DATA SHEET (SDS)
Update Date: 2026-04-24 14:58:27

What is F-Amidine (trifluoroacetate salt)?

The Uses of F-Amidine (trifluoroacetate salt)

Peptidyl arginine deiminase 4 (PAD4, Protein arginine deiminase 4) catalyzes the post-translational modification of arginine residues on histones to form citrulline, which plays a large role in regulating gene expression. Dysregulated PAD4 activity has been implicated in cancer and rheumatoid arthritis. F-amidine inhibits PAD4 activity with an IC50 value of 21.6 μM in an in vitro activity assay. It irreversibly inactivates (kinact/KI = 3,000 M-1min-1) PAD4 by covalently modifying an active site cysteine that is important for its catalytic activity. F-amidine also inhibits PAD1 and PAD3 with IC50 values of 29.5 and 350 μM, respectively. F-amidine is cytotoxic to HL-60, MCF-7, and HT-29 cancer cell lines (IC50s = 0.5, 0.5 and 1 μM, respectively).[Cayman Chemical]

Properties of F-Amidine (trifluoroacetate salt)

storage temp.	Store at -20°C
solubility	DMF: 20 mg/ml; DMSO: 20 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 10 mg/ml

Safety information for F-Amidine (trifluoroacetate salt)

Computed Descriptors for F-Amidine (trifluoroacetate salt)

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