Evolocumab

Clinical Use

IgG2 monoclonal antibody:
Treatment of hypercholesterolaemia, mixed dyslipidaemia and homozygous familial hypercholesterolaemia

Drug interactions

Potentially hazardous interactions with other drugs
Antipsychotics: avoid with clozapine - increased risk
of agranulocytosis. Vaccines: avoid concomitant use with live vaccines.

Metabolism

Evolocumab is composed of amino acids and carbohydrates as native immunoglobulin and is unlikely to be eliminated via hepatic metabolic mechanisms. Its metabolism and elimination are expected to follow the immunoglobulin clearance pathways, resulting in degradation to small peptides and individual amino acids.