Etofenamate

Chemical properties

Light Yellow Oil

Originator

Rheumon,Troponwerke,W. Germany,1977

The Uses of Etofenamate

As a histamine H1 -receptor antagonist, Etofenamate can be used as anti-inflammatory;cyclooxygenase inhibitor and medication used to alleviate joint and muscle pain.

What are the applications of Application

Etofenamate is an anti-inflammatory, anti-arrhythmic amino acid

Definition

ChEBI: 2-[3-(trifluoromethyl)anilino]benzoic acid 2-(2-hydroxyethoxy)ethyl ester is a benzoate ester.

Manufacturing Process

16.0 g (0.05 mol) of the potassium salt of N-(3-trifluoromethylphenyl)- anthranilic acid are dissolved in 60 ml of dimethylformamide and heated to 110°C, and 6.2 g (0.05 mol) of 2-(2-chloroethoxy)-ethanol are slowly added. The reaction mixture is then heated to boiling for 2 hours. The precipitated potassium chloride is filtered off and the solvent is removed by evaporation. The residue is separated over a column with 400 g of silica gel (particle size 0.05 to 0.2 mm), using a 1:1 mixture of cyclohexane and glacial acetic acid as eluting agent. 16.0 g of the 2-(2-hydroxyethoxy)-ethyl ester of N-(3- trifluoromethylphenyl)-anthranilic acid are obtained in the form of a pale yellow oil which does not crystallize and cannot be distilled.

Therapeutic Function

Antiinflammatory