Ethyl potassium malonate
Synonym(s):Monoethyl malonate potassium salt;Potassium monoethyl malonate
- CAS NO.：6148-64-7
- Empirical Formula: C5H7KO4
- Molecular Weight: 170.2
- MDL number: MFCD00035603
- EINECS: 228-156-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:10:41
What is Ethyl potassium malonate?
Chemical properties
white crystals or powder
The Uses of Ethyl potassium malonate
Ethyl potassium malonate is used as a competitive inhibitor of the enzyme succinate dehydrogenase. It acts as a precursor to produce (trimethylsilyl)ethyl malonate, which is utilized to prepare beta-ketoesters by acylation. Further, it reacts with aryl nitriles to prepare beta-amino acrylates in the presence of zinc chloride and a catalytic amount of Hünig's base. In addition to this, it serves as an intermediate for the preparation of ethyl tert-butyl malonate.
The Uses of Ethyl potassium malonate
Ethyl potassium malonate (potassium ethyl malonate) may be used to generate (trimethylsilyl)ethyl malonate in situ, which can be acylated to prepare a variety of β-ketoesters or alkylidene malonates.
What are the applications of Application
Ethyl potassium malonate is a competitive inhibitor of the enzyme succinate dehydrogenase
General Description
Ethyl potassium malonate (potassium ethyl malonate) reacts with aryl nitriles in the presence of zinc chloride and a catalytic amount of Hünig′s base to yield β-amino acrylates. Ethyl potassium malonate is formed as an intermediate during the synthesis of ethyl tert-butyl malonate.
Properties of Ethyl potassium malonate
| Melting point: | 194 °C (dec.) (lit.) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Methanol (Slightly), Water (Slightly) |
| form | Powder or Cyrstals |
| color | White |
| PH | pH(50g/l, 25℃) : 5.5～8.0 |
| Water Solubility | soluble |
| Sensitive | Hygroscopic |
| BRN | 3721682 |
| CAS DataBase Reference | 6148-64-7(CAS DataBase Reference) |
Safety information for Ethyl potassium malonate
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. |
Computed Descriptors for Ethyl potassium malonate
| InChIKey | WVUCPRGADMCTBN-UHFFFAOYSA-M |
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