Ethyl (hydroxyimino)cyanoacetate potassium salt

Chemical properties

Bright yellow powder

The Uses of Ethyl (hydroxyimino)cyanoacetate potassium salt

Ethyl (hydroxyimino)cyanoacetate potassium salt is a Non-explosive replacement for HOBt and HOAt with at least comparable performance to HOAt Outperforms HOAt in sterically demanding peptide bond formations Compatible with carbodiimide-mediated; solution and solid phase peptide coupling; Less epimerization than HOBt in fragment condensation reactions K-salt especially useful in peptide coupling on mild acid-labile resins such as 2-chlorotrityl; leading to minimal to no cleavage of the peptide from the resin due to its more alkaline character K-salt has a higher melting point than OxymaPure.

The Uses of Ethyl (hydroxyimino)cyanoacetate potassium salt

Useful in peptide coupling on mild acid-labile resins with minimal to no cleavage of the peptide from the resin due to its more alkaline character. This can be used to replace the explosive HOBt and HOAt.

The Uses of Ethyl (hydroxyimino)cyanoacetate potassium salt

• Non-explosive replacement for HOBt and HOAt with at least comparable performance to HOAt
• Outperforms HOAt in sterically demanding peptide bond formations
• Compatible with carbodiimide-mediated; solution and solid phase peptide coupling;
• Less epimerization than HOBt in fragment condensation reactions
• K-salt especially useful in peptide coupling on mild acid-labile resins such as 2-chlorotrityl; leading to minimal to no cleavage of the peptide from the resin due to its more alkaline character
• K-salt has a higher melting point than OxymaPure