Ethyl (hydroxyimino)cyanoacetate potassium salt

Synonym(s):(Z)-ethyl 2-cyano-3-hydroxyacrylate potassium salt;2-Cyano-2-(hydroxyimino)acetic acid ethyl ester, potassium salt;Ethyl (hydroxyimino)cyanoacetate potassium salt;K-Oxyma Pure

CAS NO.：158014-03-0
Empirical Formula: C5H5KN2O3
Molecular Weight: 180.2031
MDL number: MFCD26960809
SAFETY DATA SHEET (SDS)
Update Date: 2026-01-13 11:13:14

Ethyl (hydroxyimino)cyanoacetate potassium salt Structural

What is Ethyl (hydroxyimino)cyanoacetate potassium salt?

Chemical properties

Bright yellow powder

The Uses of Ethyl (hydroxyimino)cyanoacetate potassium salt

Ethyl (hydroxyimino)cyanoacetate potassium salt is a Non-explosive replacement for HOBt and HOAt with at least comparable performance to HOAt Outperforms HOAt in sterically demanding peptide bond formations Compatible with carbodiimide-mediated; solution and solid phase peptide coupling; Less epimerization than HOBt in fragment condensation reactions K-salt especially useful in peptide coupling on mild acid-labile resins such as 2-chlorotrityl; leading to minimal to no cleavage of the peptide from the resin due to its more alkaline character K-salt has a higher melting point than OxymaPure.

The Uses of Ethyl (hydroxyimino)cyanoacetate potassium salt

Useful in peptide coupling on mild acid-labile resins with minimal to no cleavage of the peptide from the resin due to its more alkaline character. This can be used to replace the explosive HOBt and HOAt.

The Uses of Ethyl (hydroxyimino)cyanoacetate potassium salt

Non-explosive replacement for HOBt and HOAt with at least comparable performance to HOAt
Outperforms HOAt in sterically demanding peptide bond formations
Compatible with carbodiimide-mediated; solution and solid phase peptide coupling;
Less epimerization than HOBt in fragment condensation reactions
K-salt especially useful in peptide coupling on mild acid-labile resins such as 2-chlorotrityl; leading to minimal to no cleavage of the peptide from the resin due to its more alkaline character
K-salt has a higher melting point than OxymaPure

Properties of Ethyl (hydroxyimino)cyanoacetate potassium salt

Melting point:	145-155°C
storage temp.	2-8°C
solubility	Methanol (Slightly), Water (Sparingly)
form	Solid
color	Dark Yellow

Safety information for Ethyl (hydroxyimino)cyanoacetate potassium salt

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06
GHS Hazard Statements	H301:Acute toxicity,oral H317:Sensitisation, Skin
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.