Ethyl benzoylformate

Synonym(s):Ethyl phenylglyoxylate

CAS NO.：1603-79-8
Empirical Formula: C10H10O3
Molecular Weight: 178.18
MDL number: MFCD00009120
EINECS: 216-504-0
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-28 02:24:28

What is Ethyl benzoylformate?

Chemical properties

clear colorless to greenish liquid

The Uses of Ethyl benzoylformate

Ethyl Benzoylformate is a general chemical reagent used in the preparation of diaminoethanediyl bismethylpyridinium salts for designing recyclable organocatalysts.

What are the applications of Application

Ethyl benzoylformate has been used in preparation of 1,5-dihydro-5-deazaflavin derivatives possessing a chiral substituent at N(3) position.

What are the applications of Application

Ethyl benzoylformate is a phenylacetate compound used as a synthetic reagent

Definition

ChEBI: Ethyl benzoylformate is the ethyl ester of phenylglyoxylic acid. Metabolite observed in cancer metabolism. It has a role as a human metabolite. It derives from a phenylglyoxylic acid.

Synthesis Reference(s)

Journal of the American Chemical Society, 82, p. 918, 1960
The Journal of Organic Chemistry, 50, p. 3573, 1985 DOI: 10.1021/jo00219a025
Tetrahedron Letters, 23, p. 3661, 1982 DOI: 10.1016/S0040-4039(00)88651-7

General Description

Enantioselective hydrogenation of ethyl benzoylformate on Pt/Al₂O₃ modified with dihydrocinchonidine has been studied.

Properties of Ethyl benzoylformate

Boiling point:	138-139 °C/18 mmHg (lit.)
Density	1.122 g/mL at 25 °C (lit.)
refractive index	1.515-1.517
Flash point:	113 °C
storage temp.	Store below +30°C.
form	Liquid
color	Clear colorless to greenish
Specific Gravity	1.122
Water Solubility	Soluble in water 1143 mg/L @ 25°C .
Sensitive	Moisture Sensitive
InChI	InChI=1S/C10H10O3/c1-2-13-10(12)9(11)8-6-4-3-5-7-8/h3-7H,2H2,1H3
CAS DataBase Reference	1603-79-8(CAS DataBase Reference)
NIST Chemistry Reference	Benzeneacetic acid, «alpha»-oxo-, ethyl ester(1603-79-8)
EPA Substance Registry System	Benzeneacetic acid, .alpha.-oxo-, ethyl ester (1603-79-8)

Safety information for Ethyl benzoylformate

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07
GHS Hazard Statements	H227:Flammable liquids H302:Acute toxicity,oral H314:Skin corrosion/irritation
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P280:Wear protective gloves/protective clothing/eye protection/face protection. P363:Wash contaminated clothing before reuse. P301+P330+P331:IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P370+P378:In case of fire: Use … for extinction. P405:Store locked up. P403+P235:Store in a well-ventilated place. Keep cool.