Ethyl 4-aminophenylacetate
- CAS NO.：5438-70-0
- Empirical Formula: C10H13NO2
- Molecular Weight: 179.22
- MDL number: MFCD00017569
- EINECS: 202-303-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-07-24 18:12:21
What is Ethyl 4-aminophenylacetate?
Chemical properties
pinkish-white to beige powder
The Uses of Ethyl 4-aminophenylacetate
Used as an intermediate in pharmaceutical research.
Synthesis
A solution of (4-nitro-phenyl)-acetic acid ethyl ester (Preparation 266, 3.4 g, 16.1 mmol) in methanol (100 mL) was degassed with argon for 15 min, treated with 10% palladium on charcoal (700 mg), and then stirred at room temperature under hydrogen (balloon pressure) for 16 hours. The reaction mixture was filtered through celite, washed with methanol (2 × 20 mL) and the filtrate Ethyl 4-aminophenylacetate was evaporated in vacuo. Yield: 96%, 2.8 g, oil. 1H NMR (400 MHz, CDCl3) δ: 1.23 (t, 3H), 3.47 (s, 2H), 3.60 (br s, 2H), 4.11 (q, 2 H), 6.63 (d, 2H), 7.05 (d, 2H).
Properties of Ethyl 4-aminophenylacetate
| Melting point: | 48-50 °C |
| Boiling point: | 120-122 °C(Press: 2 Torr) |
| Density | 1.112±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | soluble in Methanol |
| form | powder to crystal |
| pka | 4.55±0.10(Predicted) |
| color | White to Orange to Green |
| InChI | InChI=1S/C10H13NO2/c1-2-13-10(12)7-8-3-5-9(11)6-4-8/h3-6H,2,7,11H2,1H3 |
| CAS DataBase Reference | 5438-70-0(CAS DataBase Reference) |
Safety information for Ethyl 4-aminophenylacetate
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for Ethyl 4-aminophenylacetate
| InChIKey | CFNDVXUTYPXOPG-UHFFFAOYSA-N |
| SMILES | C1(CC(OCC)=O)=CC=C(N)C=C1 |
New Products
Cyclopropane-1,1-dicarboxylic acid Cefuroxime EP Impurity-A N-Nitroso hydroxy Cetrizine EP Impurity-A Noradrenaline EP Impurity D/Noradrenaline Methyl Ether Cetirizine EP Impurity A/Cetirizine CBHP Impurity Lantanoprost rc B Clidinium Bromide Impurity tert-Butyl (2S)-[1-amino-3-(4-iodophenyl)-1-oxopropan-2-yl]carbamate 4-amino-2-fluoro-N- methylbenzamide 5-Chloro-3- Methyl -1,3-2-benzoxazol-2(3H)-one N-(2-chloropyrimidin-4-yl)-N,2,3- trimethyl-2H- indazol 6-amine N-Boc-1,4-butanediamine 4-Bromo-2-fluoro-N-methylbenzamide valeronitrile 3-chlorobenzyl cyanide 3,4 Dimethoxy Benzylcyanide 3,4 Diethoxy Benzylcyanide 2-Chloro Benzylcyanide 3-Hydroxypropionitrile 5-azidovalericacid 6,6'-bis(difluoromethoxy)-2,2'-bis((3,4-dimethoxypyridin-2-yl)methylsulfinyl)-1H,1'H-5,5'-bibenzo[d]imidazole (1-((2'-(2-((1-((2'-(2H-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-butyl-4-chloro-1H-imidazol-5-yl)methyl)-2H-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-butyl-4-chloro-1H-imidazol-5-yl)methanol (1-((2'-(1-((1-((2'-(2H-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-butyl-4-chloro-1H-imidazol-5-yl)methyl)-1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-butyl-4-chloro-1H-imidazol-5-yl)methanol (4-Methoxyphenyl) hydrazine HydrochlorideRelated products of tetrahydrofuran
You may like
-
Ethyl 4-aminophenylacetate 98% CAS 5438-70-0View Details
5438-70-0 -
Ethyl 4-Aminophenylacetate CAS 5438-70-0View Details
5438-70-0 -
4-Hydroxy-6-methyl-1-(4-methylphenyl)-2naphthalenecarboxylic acid 98+View Details
101894-09-1 -
4-(6-HYDROXYHEXYLOXY)BENZOIC ACID 83883-25-4 98+View Details
83883-25-4 -
39973-47-2 NA 98+View Details
39973-47-2 -
2357109-89-6 98+View Details
2357109-89-6 -
39973-47-2 NA 98+View Details
39973-47-2 -
2357109-89-6 98+View Details
2357109-89-6
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.