ETHYL 3,4-DIHYDROXYCINNAMATE
Synonym(s):trans-3,4-Dihydroxycinnamic acid ethyl ester;trans-Caffeic acid ethyl ester
- CAS NO.：66648-50-8
- Empirical Formula: C11H12O4
- Molecular Weight: 208.21
- MDL number: MFCD00045754
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-07-27 17:00:41
What is ETHYL 3,4-DIHYDROXYCINNAMATE?
The Uses of ETHYL 3,4-DIHYDROXYCINNAMATE
Ethyl 3,4-dihydroxycinnamate shows anti-inflammatory, immunomodulatory, and anti-carcinogenic properties. It is a potent and specific inhibitor of NF-κB and its downstream inflammatory mediators: NOS2 (inducible nitric oxide synthase; NOS; NOS II), Cox-2 (cyclooxygenase-2), and prostaglandin E2 (PGE2). Ethyl 3,4-Dihydroxycinnamate prevents DNA single-strand breaks caused by H2O2.
What are the applications of Application
A Cox-2, iNOS, NOS II, and PGE2 inhibitor
Definition
ChEBI: Ethyl trans-caffeate is an ethyl ester resulting from the formal condensation of the carboxy group of trans-caffeic acid with ethanol. It has a role as an anti-inflammatory agent and an antineoplastic agent. It is an alkyl caffeate ester and an ethyl ester. It is functionally related to a trans-caffeic acid.
General Description
This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG
Properties of ETHYL 3,4-DIHYDROXYCINNAMATE
| Melting point: | 147～151℃ |
| Boiling point: | 148-149 °C |
| Density | 1.271±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| pka | 8.71±0.18(Predicted) |
| form | Off-white to brown solid. |
| color | White to off-white |
Safety information for ETHYL 3,4-DIHYDROXYCINNAMATE
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P501:Dispose of contents/container to..… |
Computed Descriptors for ETHYL 3,4-DIHYDROXYCINNAMATE
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