ethyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoate
Synonym(s):Etilevodopa;Levodopa ethyl ester;O-Ethyl-DOPA;L-Dopa ethyl ester;L-Dopa-Et
- CAS NO.：37178-37-3
- Empirical Formula: C11H15NO4
- Molecular Weight: 225.24
- MDL number: MFCD00871210
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-28 03:58:05
What is ethyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoate?
The Uses of ethyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoate
Antiparkisonian.
The Uses of ethyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoate
L-Dopa ethyl ester has been used to study the protective effects of piperlongumine (PLG) on rotenone-induced Parkinson disease (PD).
Definition
ChEBI: Etilevodopa is a tyrosine derivative.
Biochem/physiol Actions
L-Dopa ethyl ester is a prodrug of levodopa that has greater gastric solubility. The drug is rapidly hydrolyzed to levodopa by nonspecific esterases in the gastrointestinal tract. L-Dopa ethyl ester (etilevodopa)-carbidopa treatment was well tolerated but did not demonstrate better efficacy compared with standard levodopa-carbidopa treatment. L-Dopa ethyl ester should have a significant brain penetration following an administration by injection.
Properties of ethyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoate
| Boiling point: | 394.2±37.0 °C(Predicted) |
| Density | 1.278±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | H2O: ≥12mg/mL at warmed to 60°C |
| pka | 9.67±0.20(Predicted) |
| form | powder |
| color | white to tan |
Safety information for ethyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoate
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P337+P313:IF eye irritation persists: Get medical advice/attention. |
Computed Descriptors for ethyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoate
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