Esomeprazole magnesium trihydrate

Chemical properties

Off-White Powder

The Uses of Esomeprazole magnesium trihydrate

Esomeprazole magnesium trihydrate for the healing of peptic ulcers associated with non-steroidal anti-inflammatory drug NSAID (non-selective and COX-2 selective) therapy.
Zollinger-Ellison syndrome
Peptic ulcer, site unspecified
Duodenal ulcer
Gastric ulcer
Gastro-oesophageal reflux disease

The Uses of Esomeprazole magnesium trihydrate

S-Form of Omeprazole. Gastric proton-pump inhibitor

brand name

Nexium (AstraZeneca).

Description

Esomeprazole magnesium trihydrate ((S)-Omeprazole magnesium trihydrate) is a potent, orally active H+, K+-ATPase inhibitor. It has the potential for upper intestinal disorders and gastroesophageal reflux disease research. Esomeprazole magnesium trihydrate acts as an exosome inhibitor by blocking the exosome release by inhibiting V-H+-ATPases.

Definition

Esomeprazole Magnesium is the magnesium salt of esomeprazole, the S-isomer of omeprazole, with gastric proton pump inhibitor activity. In the acidic compartment of parietal cells, esomeprazole is protonated and converted into the active achiral sulphenamide; the active sulphenamide forms one or more covalent disulfide bonds with the proton pump hydrogen-potassium adenosine triphosphatase (H+/K+ ATPase), thereby inhibiting its activity and the parietal cell secretion of H+ ions into the gastric lumen, the final step in gastric acid production. H+/K+ ATPase is an integral membrane protein of the gastric parietal cell.