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Eprazinone

  • CAS NO.:10402-90-1
  • Empirical Formula: C24H32N2O2
  • Molecular Weight: 380.52
  • MDL number: MFCD00866843
  • EINECS: 233-873-3
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2026-05-27 23:53:01
Eprazinone Structural

What is Eprazinone?

Originator

Mucitux,Riom,France,1969

Definition

ChEBI: A member of the class of piperazines in which the two amino hydrogens of piperazine are replaced by 2-benzoylpropyl and 2-ethoxy-2-phenylethyl groups.

Manufacturing Process

61.4 g of 0.2M of 1-(2-phenyl-2-ethoxy)piperazine dihydrochloride, 33.5 g (0.25M) propiophenone, 75 g (0.25M) trioxymethylene, 120 ml of ethanol and 0.4 ml of concentrated HCl are heated under reflux for 4 to 5 hours. The product is allowed to crystallize, then filtered and washed with alcohol. It is dried and recrystallized from methanol containing 10% H2O.
There is thus obtained 60 g of a white crystalline powder soluble in water. Yield: 66%. Melting point: 160°C.

Therapeutic Function

Antitussive

Properties of Eprazinone

Boiling point: 508.13°C (rough estimate)
Density  1.0909 (rough estimate)
refractive index  1.5500 (estimate)
storage temp.  Sealed in dry,Room Temperature
pka 6.83±0.10(Predicted)
CAS DataBase Reference 10402-90-1(CAS DataBase Reference)

Safety information for Eprazinone

Computed Descriptors for Eprazinone

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