ENPROFYLLINE

Absorption

Rapidly absorbed from the digestive tract

Description

3-Propylxanthine is a xanthine derivative that antagonizes adenosine receptors (K_is = 44, 32, and 6.3 μM for A₁, A_2A, and A_2B, respectively) and cAMP phosphodiesterase (K_i = 42 μM). Through these actions, 3-propylxanthine induces smooth muscle relaxation, blocks smooth muscle contraction and VEGF secretion driven by adenosine receptor agonists, and reduces bronchial hyperresponsiveness.

The Uses of ENPROFYLLINE

Enprofylline is a xanthine lacking adenosine receptor antagonism.

The Uses of ENPROFYLLINE

Bronchodilator.

Background

Enprofylline is a derivative of theophylline which shares bronchodilator properties. Enprofylline is used in asthma, chronic obstructive pulmonary disease, and in the management of cerebrovascular insufficiency, sickle cell disease, and diabetic neuropathy. Long-term enprofylline administration may be associated with elevation in liver enzyme levels and unpredictable blood levels.

Indications

Used in the management of symptoms of asthma. Also used in the treatment of peripheral vascular diseases and in the management of cerebrovascular insufficiency, sickle cell disease, and diabetic neuropathy.

What are the applications of Application

3-Propylxanthine is a weak competitor antagonist at both A1 and A2 adenosine receptors

Definition

ChEBI: Xanthine bearing a propyl substituent at position 3. A bronchodilator, it is used for the symptomatic treatment of asthma and chronic obstructive pulmonary disease, and in the management of cerebrovascular insufficiency, sickle cell disease, and diabetic n uropathy.

Pharmacokinetics

Enprofylline is a synthetic dimethylxanthine derivative structurally related to theophylline and caffeine. It antagonizes erythrocyte phosphodiesterase, increasing cAMP activity.

Metabolism

Not Available