Eltanolone
Synonym(s):3α-Hydroxy-5β-pregnan-20-one;3α-Hydroxy-5β-tetrahydroprogesterone;Pregnanolone
- CAS NO.：128-20-1
- Empirical Formula: C21H34O2
- Molecular Weight: 318.49
- MDL number: MFCD00067137
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-04-24 14:58:17
What is Eltanolone?
The Uses of Eltanolone
A hyponotic-anaesthetic agent
The Uses of Eltanolone
A hyponotic-anaesthetic agent.
What are the applications of Application
5β-Pregnan-3α-ol-20-one is a simple derivitized steroid
Definition
ChEBI: The 3alpha-stereoisomer of 3-hydroxy-5beta-pregnan-20-one.
Biological Activity
GABA A receptor positive allosteric modulator. Neuroactive steroid.
Biochem/physiol Actions
5β-Pregnan-3α-ol-20-one or pregnanolone is a neurosteroid that acts as a positive allosteric modulator (PAMs) of γ-aminobutyric acid A receptors (GABAARs). It mediates anti-convulsive, anxiolytic and sedative effects. Pregnanolone inhibits γ-aminobutyric acid C receptor (GABAC) receptor-based response and favors GABAA?receptor-mediated currents.
Storage
Store at RT
Properties of Eltanolone
| Melting point: | 149°C |
| Boiling point: | 397.64°C (rough estimate) |
| alpha | D23 +59.6° (c = 0.3 in chloroform); D26 +108.5 ±1° (c = 9.23 mg/1.23 ml abs ethanol) |
| Density | 1.0234 (rough estimate) |
| refractive index | 1.5344 (estimate) |
| storage temp. | Store at RT |
| solubility | Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 15.12±0.70(Predicted) |
| color | White to Off-White |
| Water Solubility | 8mg/L(room temperature) |
| NIST Chemistry Reference | 3Alpha-hydroxy-5beta-pregnan-20-one(128-20-1) |
Safety information for Eltanolone
| Signal word | Warning |
| Pictogram(s) |
 Health Hazard GHS08 |
| GHS Hazard Statements |
H351:Carcinogenicity |
| Precautionary Statement Codes |
P281:Use personal protective equipment as required. |
Computed Descriptors for Eltanolone
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![Pregnanolone-[d5] (Solution)](https://img.chemicalbook.in/)
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