EIPA

Synonym(s):EIPA

CAS NO.：1154-25-2
Empirical Formula: C11H18ClN7O
Molecular Weight: 299.76
MDL number: MFCD00151710
SAFETY DATA SHEET (SDS)
Update Date: 2025-12-09 14:49:44

What is EIPA?

Description

Sodium-hydrogen exchangers (NHE) are involved in maintaining sodium and pH balance in a variety of tissues. They are also known as sodium-hydrogen antiporters and solute carrier family 9 members. 5-(N-ethyl-N-isopropyl)-Amiloride (EIPA) is a potent inhibitor of several NHE isoforms, inhibiting NHE1, NHE2, NHE3, and NHE5 with K_i values of 0.02, 0.5, 2.4, and 0.42 μM, respectively. It less effectively inhibits NHE4 (IC₅₀ ≥10 μM). EIPA is commonly used at a concentration of 5-10 μM to inhibit cellular HNE activity.

Chemical properties

Yellow Solid

The Uses of EIPA

Selective Na+/H+ antiporter inhibitor. Selectively enhances the excretion of sodium ions without causing an increase in excretion of potassium ions

The Uses of EIPA

Selective Na+/H+ antiporter inhibitor. Selectively enhances the excretion of sodium ions without causing an increase in excretion of potassium ions.

The Uses of EIPA

5-(N-Ethyl-N-isopropyl)amiloride has been used:

as a supplement in endothelial cell growth medium to incubate human lung microvascular endothelial cell
in Pluronic F-127 stock solution for Drosophila larval live-imaging
in choline chloride solution as an experimental perfusate, to study the effect of Na⁺/H⁺ inhibition on jejunal loop perfusion in vivo

What are the applications of Application

5-(N-Ethyl-N-isopropyl)-Amiloride is a selective Na+/H+ antiporter inhibitor

Definition

ChEBI: Ethylisopropylamiloride is a member of the class of pyrazines that is amiloride in which the amino substitutent of the pyrazine ring that is adjacent to the chloro substituent has been substituted by an ethyl group and by an isopropyl group. It has a role as an anti-arrhythmia drug, a neuroprotective agent and a sodium channel blocker. It is a member of guanidines, an aromatic amine, an organochlorine compound, a tertiary amino compound, a member of pyrazines and a monocarboxylic acid amide. It is functionally related to an amiloride.

Biochem/physiol Actions

Selective blocker of Na+/H+ antiport

Storage

Store at +4°C

Properties of EIPA

Melting point:	202-205 °C(lit.)
Density	1.49±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,2-8°C
solubility	Acetonitrile (Slightly, Heated), DMSO (Slightly), Methanol (Slightly)
form	Off-white to yellow solid.
pka	8.67±0.46(Predicted)
color	Pale Yellow to Green
Stability:	Unstable in methanol
CAS DataBase Reference	1154-25-2

Safety information for EIPA

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.