Edoxaban-d6
- CAS NO.：1304701-57-2
- Empirical Formula: C24H24ClD6N7O4S
- Molecular Weight: 554.1
- MDL number: MFCD32661438
- Update Date: 2026-07-30 08:05:31
What is Edoxaban-d6?
Description
Edoxaban-d6 is intended for use as an internal standard for the quantification of edoxaban by GC- or LC-MS. Edoxaban is an orally bioavailable and potent inhibitor of factor Xa (Kis = 0.561 and 0.903 nM for free and complexed human factor Xa, respectively). It is >10,000-fold selective for factor Xa over thrombin, FVIIa/sTF, FXIa, tPA, aPC, trypsin, plasmin, and chymotrypsin. Edoxaban prolongs prothrombin, activated partial thromboplastin, and thrombin clotting times in a concentration-dependent manner ex vivo in human plasma. Oral administration of edoxaban (0.5-12.5 mg/kg) reduces thrombus formation and prolongs prothrombin time in a dose-dependent manner in rat and rabbit models of venous stasis thrombosis. It also reduces thrombus formation in a rat model of platinum wire-induced venous thrombosis. Formulations containing edoxaban have been used to prevent stroke in patients with atrial fibrillation.
The Uses of Edoxaban-d6
Edoxaban-d6 is the isotope labelled analog of Edoxaban (E555520); an anticoagulant drug which acts as a direct factor Xa inhibitor.
Properties of Edoxaban-d6
| Melting point: | >205°C (dec.) |
| storage temp. | Hygroscopic, Refrigerator, under inert atmosphere |
| solubility | Chloroform (Slightly), Dichloromethane (Slightly) |
| form | Solid |
| color | Pale Orange to Pale Red |
| Stability: | Hygroscopic |
Safety information for Edoxaban-d6
Computed Descriptors for Edoxaban-d6
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