Econazole nitrate
- CAS NO.：68797-31-9
- Empirical Formula: C18H16Cl3N3O4
- Molecular Weight: 444.7
- MDL number: MFCD00058160
- EINECS: 272-295-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:24:16
What is Econazole nitrate?
Description
Econazole nitrate (EN) is a broad-spectrum antifungal medication used topically in the treatment of dermatomycoses due to a wide variety of fungi, such as athlete’s foot, jock itch, ringworm, and pityriasis. It is also used vaginally in the treatment of vaginal candidosis.
The Uses of Econazole nitrate
Antifungal.
brand name
Spectazole (Johnson & Johnson).
General Description
1-[2-[(4-Chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)-ethyl]-1H-imidazole (Spectazole) is a white crystalline nitricacid salt of econazole. It is only slightly soluble in waterand most organic solvents.Econazole is used as a 1% cream for the topical treatmentof local tinea infections and cutaneous candidiasis.
References
[1] P. Verma, B. Pharm, M. Pharm, K. Pathak, M. Pahrm, Nanosized ethanolic vesicles loaded with econazole nitrate for the treatment of deep fungal infections through topical gel formulation, Nanomedicine: Nanotechnology, Biology, and Medicine, 2012, vol. 8, 489-496
[2] R. C. Heel, R. N. Brogden, T. M. Speight and G. S. Avery, Econazole: A Review of its Antifungal Activity and Therapeutic Efficacy, Drugs, 1978, vol. 16, 177-201
[3] http://www.webmd.com
Properties of Econazole nitrate
| Density | 1.6311 (rough estimate) |
| refractive index | 1.6200 (estimate) |
| form | neat |
| Water Solubility | 711.5mg/L(25 ºC) |
| CAS DataBase Reference | 68797-31-9(CAS DataBase Reference) |
Safety information for Econazole nitrate
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Econazole nitrate
| InChIKey | DDXORDQKGIZAME-UHFFFAOYSA-N |
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