EC 5.4.2.2

Synonym(s):α-D-Glucose-1,6-bisphosphatase;α-D-Glucose-1-phosphate phosphotransferase

CAS NO.：9001-81-4
Empirical Formula: NULL
Molecular Weight: 0
MDL number: MFCD00131886
EINECS: 232-634-0
Update Date: 2026-05-28 02:54:20

What is EC 5.4.2.2?

Chemical properties

White to light yellow solid

The Uses of EC 5.4.2.2

Phosphoglucomutase exchanges a phosphoryl group with the substrate.

The Uses of EC 5.4.2.2

Phosphoglucomutase from rabbit muscle may be used in dephosphorylation to investigate the hexose bisphosphate activation of phosphoglucomutase.

General Description

The phosphoglucomutase (PGM) molecule, a single polypeptide chain, is made up of four α/β domains. The domains form a compact heart-shaped structure with a large fissure between the two lobes, and the molecule comprises about 40 secondary structural components. The active enzymatic site of the molecule is located at the bottom of the crevice on the surface of domain I. Rabbit muscle phosphoglucomutase (RB-PGM) is a monomer with unique four-domain architecture.

Biochem/physiol Actions

Phosphoglucomutase (PGM) mainly catalyzes the interconversion of glucose 1-phosphate and glucose 6-phosphate via a glucose 1,6-diphosphate intermediate. Hence it plays a key role in glycolysis and gluconeogenesis.

Properties of EC 5.4.2.2

Density	1.00 g/mL at 20 °C
storage temp.	-20°C
form	ammonium sulfate suspension
color	White to off-white
EPA Substance Registry System	Phosphomutase, glucose (9001-81-4)

Safety information for EC 5.4.2.2

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection.