Ebastine

Synonym(s):1-[4-(1,1-Dimethylethyl)phenyl]-4-[4-(diphenylmethoxy)-1-piperidinyl]-1-butanone

CAS NO.：90729-43-4
Empirical Formula: C32H39NO2
Molecular Weight: 469.66
MDL number: MFCD00865661
EINECS: 635-609-6
SAFETY DATA SHEET (SDS)
Update Date: 2024-03-15 13:40:56

What is Ebastine?

Description

Ebastine is a new once-daily histamine Hl-receptor antagonist with no sedative effects or autonomic impairment at therapeutic doses. It is reported to be effective in the treatment of hay fever, perennial rhinitis, and uticaria. Ebastine's antihistamine activity is attributed to its carboxylic acid metabolite carebastine.

The Uses of Ebastine

Ebastine is a second-generation H1 receptor antagonist that is indicated mainly for allergic rhinitis and chronic idiopathic urticaria. It is available in 10 and 20 mg tablets and as fast-dissolving tablets, as well as in pediatric syrup. It has a recommended flexible daily dose of 10 or 20 mg, depending on disease severity.

Background

Ebastine is under investigation for the treatment of Irritable Bowel Syndrome (IBS). Ebastine has been investigated for the treatment of Urticaria.

What are the applications of Application

Ebastine is an antagonist of the histamine H1-receptor

Metabolism

Properties of Ebastine

Melting point:	80-82°C
Boiling point:	596.3±50.0 °C(Predicted)
Density	1.09±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	Slightly soluble in chloroform, methanol.
form	solid
color	white

Safety information for Ebastine

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H303:Acute toxicity,oral
Precautionary Statement Codes	P270:Do not eat, drink or smoke when using this product. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P403:Store in a well-ventilated place.