E 7010
- CAS NO.：141430-65-1
- Empirical Formula: C18H17N3O4S
- Molecular Weight: 371.41
- MDL number: MFCD00910291
- EINECS: 256-495-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-07-14 16:49:18
What is E 7010?
Description
ABT-751 is a tubulin polymerization inhibitor that binds to the colchicine binding site on β-tubulin (Ki = 3.3 μM). It inhibits tubulin polymerization in a concentration-dependent manner and inhibits growth of 26 human tumor cell lines (IC50s = 0.06-0.08 μg/ml). ABT-751 (100 mg/kg, p.o.) induces tumor regression in NB-1382 neuroblastoma, IRS56 rhabdomyosarcoma, and KT-6 Wilms mouse xenograft models. It also induces tumor endothelial cell retraction and reduces tumor perfusion, but not muscle perfusion, in a 9L rat glioma subcutaneous tumor model.
What are the applications of Application
ABT 751 is an inhibitor of microtubule polymerization
Definition
ChEBI: N-[2-(4-hydroxyanilino)-3-pyridinyl]-4-methoxybenzenesulfonamide is a sulfonamide.
Properties of E 7010
| Melting point: | 162 °C(dec.) |
| Boiling point: | 551.0±60.0 °C(Predicted) |
| Density | 1.427 |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| solubility | insoluble in H2O; ≥18.55 mg/mL in DMSO; ≥25.53 mg/mL in EtOH with ultrasonic |
| pka | 7.86±0.40(Predicted) |
| form | powder to crystal |
| color | White to Yellow to Orange |
Safety information for E 7010
Computed Descriptors for E 7010
New Products
5-bromo-4-fluoro-2-nitrobenzaldehyde (R)-(-)-2-Amino-1-propanol Cyclobutanone Fmoc-OSu 1-(2-Chloroethyl)pyrrolidine Hydrochloride 2-Amino-2-(4-methylphenyl)acetic acid β-Bromostyrene Ethyl 3-phenylpropanoate Phenethyl cinnamate Dipropyl disulfide 4 pentyn 1 ol N-Vinylformamide Methacrylate-PEG-Methacrylate, Mn:35000 2,4-Dihydroxyacetophenone 2-Chloro 5-Fluoro Pyridine Vasicinone 2-Chloroisonicotinic Acid Tween 80 or Polysorbate 80 2-Butyn-1-oL 2-Pentyn-1-oL 4-Nitrobenzotrifluoride N-(4-fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indol-3-yl)pyrimidin-2-amine Pirtobrutinib intd. N-(4-Cyano-3-(trifluoromethyl)phenyl)-2-methyloxirane-2-carboxamideRelated products of tetrahydrofuran
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