E 7010
- CAS NO.：141430-65-1
- Empirical Formula: C18H17N3O4S
- Molecular Weight: 371.41
- MDL number: MFCD00910291
- EINECS: 256-495-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-06-03 11:24:09
What is E 7010?
Description
ABT-751 is a tubulin polymerization inhibitor that binds to the colchicine binding site on β-tubulin (Ki = 3.3 μM). It inhibits tubulin polymerization in a concentration-dependent manner and inhibits growth of 26 human tumor cell lines (IC50s = 0.06-0.08 μg/ml). ABT-751 (100 mg/kg, p.o.) induces tumor regression in NB-1382 neuroblastoma, IRS56 rhabdomyosarcoma, and KT-6 Wilms mouse xenograft models. It also induces tumor endothelial cell retraction and reduces tumor perfusion, but not muscle perfusion, in a 9L rat glioma subcutaneous tumor model.
What are the applications of Application
ABT 751 is an inhibitor of microtubule polymerization
Definition
ChEBI: N-[2-(4-hydroxyanilino)-3-pyridinyl]-4-methoxybenzenesulfonamide is a sulfonamide.
Properties of E 7010
| Melting point: | 162 °C(dec.) |
| Boiling point: | 551.0±60.0 °C(Predicted) |
| Density | 1.427 |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| solubility | insoluble in H2O; ≥18.55 mg/mL in DMSO; ≥25.53 mg/mL in EtOH with ultrasonic |
| pka | 7.86±0.40(Predicted) |
| form | powder to crystal |
| color | White to Yellow to Orange |
Safety information for E 7010
Computed Descriptors for E 7010
New Products
6-Hydroxy-2,4-Diaminopyrimidine 2,6-Dipicolic Acid 3-AMINO-3-(2-CHLORO-PHENYL)-PROPIONIC ACID 4-Fluorophenylglycine 1-N-Boc-3-(aminoethyl)azetidine Dimedone 1-Boc-3-(cyanomethyl)azetidine N-BOC-piperidine-4-carboxylic acid 3-Hydroxypyridine 2-Bromo-5-Chloro-3-Nitropyridine 2-Amino-3-Nitro-5-Chloro Pyridine 2-Amino-5-Iodopyridine 5-Amino-2-Hydroxypyridine 2,5-Dibromopyridine 2-BROMOACETYL BROMIDE-D2 METHANE SULFONIC ACID-D4 PHOSPORIC ACID-D3 85 W% IN D2O DEUTERIUM OXIDE FOR NMR BENZENE-D6 TOLUENE-D3 5-Acetylsalicylamide 1-(3-Chlorophenyl)-4-(3-Chloropropyl) piperazine hydrochloride 4-(Methyl amino)-3-Nitro benzoic acid 3,4,5-Trimethoxy benzoic acidRelated products of tetrahydrofuran
You may like
-
ABT-751 CAS 141430-65-1View Details
141430-65-1 -
67914-85-6 cis-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolane-4-methanol (IT8)View Details
67914-85-6 -
350-03-8 3-AcetylpyridineView Details
350-03-8 -
6-Chloro-2,4-Diamino pyrimidine 156-83-2View Details
156-83-2 -
1-(4-Aminophenyl)-4-(4-methoxyphenyl)Piperazine 74852-62-3View Details
74852-62-3 -
556-08-1 4-Acetamidobenzoic acidView Details
556-08-1 -
5-Bromo-2-Chlorobenzoic acid 21739-92-4View Details
21739-92-4 -
15128-52-6View Details
15128-52-6
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.