DOTMA

CAS NO.：104872-42-6
Empirical Formula: C42H84ClNO2
Molecular Weight: 670.59
SAFETY DATA SHEET (SDS)
Update Date: 2026-07-16 07:06:08

What is DOTMA?

Description

DOTMA is one of the first cationic lipid used for gene transfection. DOTMA carries a positive charge on the surface of liposomes which condenses anionic nucleic acids and promotes efficient interactions between the cell membrane and the liposome.

The Uses of DOTMA

DOTMA is used for drug delivery and gene transfection. When used as a component of liposomes, it is used to encapsulate siRNAs, miRNAs and oligonucleotides, etc., to form carrier liposomes (LPX), which are used in anticancer vaccine research.DOTMA has shown good gene transfection effects both in vitro and in vivo. It can also be used as a development of new visualisers.

Biochem/physiol Actions

DOTMA is a cationic lipid, used as a non-viral vector for gene therapy. It exhibits effective in vitro and in vivo gene transfection. DOTMA induces a positive charge on the liposomes and thus promotes efficient liposome - cell membrane interaction.

Properties of DOTMA

solubility	DMSO:50.0(Max Conc. mg/mL);0.03(Max Conc. mM)
form	Solid
color	White to light yellow

Safety information for DOTMA

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention.