Dolutegravir Impurity 8
- CAS NO.：2244161-72-4
- Empirical Formula: C20H19F2N3O5
- Molecular Weight: 419.38
- Update Date: 2024-04-25 17:59:01
What is Dolutegravir Impurity 8?
The Uses of Dolutegravir Impurity 8
4-Desfluoro-6-fluoro Dolutegravir is impurity C of Dolutegravir (D528800), which is a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir is currently in Phase III clinical trials for the treatment of HIV infection. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector.
Properties of Dolutegravir Impurity 8
| Boiling point: | 664.9±55.0 °C(Predicted) |
| Density | 1.53±0.1 g/cm3(Predicted) |
| pka | 4.50±1.00(Predicted) |
Safety information for Dolutegravir Impurity 8
Computed Descriptors for Dolutegravir Impurity 8
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AMino-(3-Methylphenyl)-acetic acid 3-AMINO-3-(2-CHLORO-PHENYL)-PROPIONIC ACID 4-Fluorophenylglycine 1-Boc-3-(cyanomethyl)azetidine Dimedone 1-N-Boc-3-(aminoethyl)azetidine 4,6-Dichlororesorcinol 5-Amino-2-Bromo-3-Chloropyridine 2-Picolinic acid N-oxide 4-Butyl Resorcinol 2-Bromo-5-Chloropyridine 5-Bromo-2-Hydroxy-3-Nitro Pyridine 4-Chloro-2-methyl quinoline 2-Amino-4-phenyl-thiazole N-(4-Bromophenyl)-2-chloroacetamide DEUTERIUM CHLORIDE ETHANOL-D1(OD) PHENYL-D5-BORONIC ACID TOLUENE-D8 METHANOL-D4 DIMETHYLSULFATE-D6Related products of tetrahydrofuran
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