DODAP

Synonym(s):1,2-dioleoyl-3-dimethylammonium-propane (DODAP)

CAS NO.：127512-29-2
Empirical Formula: C41H77NO4
Molecular Weight: 648.05
MDL number: MFCD01321074
SAFETY DATA SHEET (SDS)
Update Date: 2026-07-18 07:23:31

What is DODAP?

Description

DODAP (18:1) is an ionizable cationic lipid with lower cytotoxicity and high transfection efficiency. DODAP is neutral at physiological pH, but acquires a positive charge inside the endosome due to the protonation of free amines when pH is lower than its pKa (<7).

Chemical properties

Light Yellow Oil

The Uses of DODAP

Cationic amphiphiles are being studied for their potential role in preparing liposomes for interaction with artificial and biological membranes and cellular transfection techniques. Cationic species with ester linkages to the hydrophobic portion are more easily degraded by recipient cells and more efficiently metabolized.

Properties of DODAP

Boiling point:	670.1±55.0 °C(Predicted)
Density	0.916±0.06 g/cm3(Predicted)
storage temp.	-20°C Freezer, Under Inert Atmosphere
solubility	Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form	Oil
pka	8.02±0.28(Predicted)
color	Colourless to Light Yellow
Stability:	Light Sensitive; Hydroscopic; Store at -15 to -25°C

Safety information for DODAP

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06 Health Hazard GHS08
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H331:Acute toxicity,inhalation H336:Specific target organ toxicity,single exposure; Narcotic effects H351:Carcinogenicity H372:Specific target organ toxicity, repeated exposure
Precautionary Statement Codes	P202:Do not handle until all safety precautions have been read and understood. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P308+P313:IF exposed or concerned: Get medical advice/attention.