DM3-Sme

CAS NO.：796073-70-6
Empirical Formula: C38H54ClN3O10S2
Molecular Weight: 812.43
MDL number: MFCD28400103
SAFETY DATA SHEET (SDS)
Update Date: 2025-04-17 18:22:24

What is DM3-Sme?

Description

DM3-SMe is a maytansine derivative and a tubulin inhibitor, and is a cytotoxic moiety of antibody-drug conjugates (ADCs), which can be linked to antibody through disulfide bond or stable thioether bond. DM3-SMe shows highly cytotoxic activity in vitro with an IC50 of 0.0011 nM[1][2].

References

[1]. Chen H, et al. Tubulin Inhibitor-Based Antibody-Drug Conjugates for Cancer Therapy. Molecules. 2017 Aug 1;22(8). [2]. Yuliang Zhaoet al. Biomedical Nanomaterials. 2016-‎Science.

Properties of DM3-Sme

Boiling point:	962.6±65.0 °C(Predicted)
Density	1.31±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	Soluble in DMSO
pka	9.82±0.70(Predicted)

Safety information for DM3-Sme

Computed Descriptors for DM3-Sme

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