DL-Propargylglycine

CAS NO.：16900-57-5
Empirical Formula: C5H7NO2.ClH
Molecular Weight: 149.58
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-28 01:05:09

What is DL-Propargylglycine?

Description

Hydrogen sulphide (H₂S), a naturally occurring gasotransmitter, is a potent vasodilator and pro-inflammatory mediator. DL-Propargyl glycine (PAG) is an irreversible inhibitor of the H₂S synthesizing enzyme cystathionine-γ-lyase (CSE). PAG blocks H₂S synthesis activity in rat liver preparations with an IC₅₀ value of 55 μM and abolishes the rise in plasma H₂S in anaesthetized rats induced with hemorrhagic shock. At concentrations ranging from 25-100 mg/kg, PAG can reduce H₂S-associated inflammation in rodent models of pancreatitis, oedema, and endotoxemia.

The Uses of DL-Propargylglycine

DL-Propargylglycine Hydrochloride is used in preparation of tert-Butoxycarbonyl Azide.

What are the applications of Application

DL-Propargylglycine (hydrochloride) is an irreversible inhibitor of the H2S synthesizing enzyme CSE

Properties of DL-Propargylglycine

storage temp.	Inert atmosphere,Room Temperature
solubility	DMF: 20 mg/ml; DMSO: 20 mg/ml; Ethanol: 20 mg/ml; PBS (pH 7.2): 10 mg/ml
form	A crystalline solid

Safety information for DL-Propargylglycine

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for DL-Propargylglycine

New Products

2-(2-Chlorophenyl)glycine Propiolic Acid 1-(3-Hydroxy-4-methoxyphenyl)-2-nitroethene (±)-amino(2-fluorophenyl)acetic acid trans-3-Benzyloxy-4-methoxy-beta-nitrostyrene 1-Pentadecanol 4-(4-Αminophenyl)-3-Morpholinone 3-Morpholino-1-(4-(2-oxopiperidin-1-yl) phenyl)-5,6-dihyropyridin-2-(1H)-one 1-(4-Aminophenyl)-3-morpholino-5,6-dihydropyridin-2(1H)-one N-cyanoacetylurethane 1H-Indazole