DL-METHIONINE METHYLSULFONIUM CHLORIDE
Synonym(s):(3-Amino-3-carboxypropyl)dimethyl sulfonium chloride;Methyl-methionine sulphonium chloride;MMS;Vitamin U
- CAS NO.：3493-12-7
- Empirical Formula: C6H14NO2S.Cl
- Molecular Weight: 199.7
- MDL number: MFCD00031700
- EINECS: 222-484-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-03-13 15:00:32
What is DL-METHIONINE METHYLSULFONIUM CHLORIDE?
Description
DL-Methionine methylsulfonium chloride, also named Vitamin U, is a powerful antioxidant. It is a sulfur derivative substance. Graviola leaves contain much vitamin U[1]. Vitamin U have unique antioxidant effect. It could prevents Galactosamine-induced gastric damage and protects pentylenetetrazole-induced brain damage in rats[2-3].
The Uses of DL-METHIONINE METHYLSULFONIUM CHLORIDE
DL-Methionine Methylsulfonium Chloride is a compound comprised of γ-glutamyl peptide and amino acid that have a sucrose-like taste.
The Uses of DL-METHIONINE METHYLSULFONIUM CHLORIDE
Vitamin U (DL-methionine methylsulfonium chloride) is a natural methionine-derivative, found as an active component in the methionine cycle of plants where it serves as a substrate for methyl transferases (Augspurger et al., 2005). Historically this compound has been utilized as either a cure or preventative against gastric and duodenal ulcers (Nakamura et al., 1981).
Biochem/physiol Actions
S-Methionine methylsulfonium (SMMS) chloride is a derivative of methionine metabolism in some plants. SMMS has potent therapeutic effects on gastrointestinal ulceration potentially via its ability to promote dermal fibroblast migration and growth.
References
[1] Choi E, et al. Increased Intestinal Absorption of Vitamin U in Steamed Graviola Leaf Extract Activates Nicotine Detoxification. Nutrients, 2019; 11.
[2] Topaloglu D, et al. Gastroprotective effect of vitamin U in D-galactosamine-induced hepatotoxicity. Journal of Biochemical and Molecular Toxicology, 2022; 36: e23124.
[3] Bayrak G, et al. The protective effect of vitamin U on pentylenetetrazole-induced brain damage in rats, 2022; 36: e23169.
Properties of DL-METHIONINE METHYLSULFONIUM CHLORIDE
| Melting point: | 139-140 °C (dec.) |
| FEMA | 3445 | DL-(3-AMINO-3-CARBOXYPROPYL)DIMETHYLSULFONIUM CHLORIDE |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | H2O: soluble100mg/mL, clear, colorless |
| form | Solid |
| color | White to Off-White |
| PH | 4.0-5.5 |
| Water Solubility | Water: 250 mg/mL (1251.88 mM) |
| Merck | 14,6098 |
| JECFA Number | 1427 |
| BRN | 4163617 |
| Stability: | Hygroscopic |
| CAS DataBase Reference | 3493-12-7(CAS DataBase Reference) |
| EPA Substance Registry System | Sulfonium, (3-amino-3-carboxypropyl)dimethyl-, chloride (3493-12-7) |
Safety information for DL-METHIONINE METHYLSULFONIUM CHLORIDE
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for DL-METHIONINE METHYLSULFONIUM CHLORIDE
| InChIKey | MYGVPKMVGSXPCQ-UHFFFAOYSA-N |
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