DL-METHIONINE METHYLSULFONIUM CHLORIDE

Synonym(s):(3-Amino-3-carboxypropyl)dimethyl sulfonium chloride;Methyl-methionine sulphonium chloride;MMS;Vitamin U

CAS NO.：3493-12-7
Empirical Formula: C6H14NO2S.Cl
Molecular Weight: 199.7
MDL number: MFCD00031700
EINECS: 222-484-4
SAFETY DATA SHEET (SDS)
Update Date: 2026-07-16 07:06:08

DL-METHIONINE METHYLSULFONIUM CHLORIDE Structural

What is DL-METHIONINE METHYLSULFONIUM CHLORIDE?

Description

DL-Methionine methylsulfonium chloride, also named Vitamin U, is a powerful antioxidant. It is a sulfur derivative substance. Graviola leaves contain much vitamin U[1]. Vitamin U have unique antioxidant effect. It could prevents Galactosamine-induced gastric damage and protects pentylenetetrazole-induced brain damage in rats[2-3].

The Uses of DL-METHIONINE METHYLSULFONIUM CHLORIDE

DL-Methionine Methylsulfonium Chloride is a compound comprised of γ-glutamyl peptide and amino acid that have a sucrose-like taste.

The Uses of DL-METHIONINE METHYLSULFONIUM CHLORIDE

Vitamin U (DL-methionine methylsulfonium chloride) is a natural methionine-derivative, found as an active component in the methionine cycle of plants where it serves as a substrate for methyl transferases (Augspurger et al., 2005). Historically this compound has been utilized as either a cure or preventative against gastric and duodenal ulcers (Nakamura et al., 1981).

Biochem/physiol Actions

S-Methionine methylsulfonium (SMMS) chloride is a derivative of methionine metabolism in some plants. SMMS has potent therapeutic effects on gastrointestinal ulceration potentially via its ability to promote dermal fibroblast migration and growth.

References

[1] Choi E, et al. Increased Intestinal Absorption of Vitamin U in Steamed Graviola Leaf Extract Activates Nicotine Detoxification. Nutrients, 2019; 11.
[2] Topaloglu D, et al. Gastroprotective effect of vitamin U in D-galactosamine-induced hepatotoxicity. Journal of Biochemical and Molecular Toxicology, 2022; 36: e23124.
[3] Bayrak G, et al. The protective effect of vitamin U on pentylenetetrazole-induced brain damage in rats, 2022; 36: e23169.

Properties of DL-METHIONINE METHYLSULFONIUM CHLORIDE

Melting point:	139-140 °C (dec.)
FEMA	3445 \| DL-(3-AMINO-3-CARBOXYPROPYL)DIMETHYLSULFONIUM CHLORIDE
storage temp.	Inert atmosphere,Room Temperature
solubility	H2O: soluble100mg/mL, clear, colorless
form	Solid
color	White to Off-White
PH	4.0-5.5
Water Solubility	Water: 250 mg/mL (1251.88 mM)
Merck	14,6098
JECFA Number	1427
BRN	4163617
Stability:	Hygroscopic
CAS DataBase Reference	3493-12-7(CAS DataBase Reference)
EPA Substance Registry System	Sulfonium, (3-amino-3-carboxypropyl)dimethyl-, chloride (3493-12-7)

Safety information for DL-METHIONINE METHYLSULFONIUM CHLORIDE

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.