DL-Histidine
Synonym(s):(S)-2-Amino-3-(4-imidazolyl)propionic acid;(±)-2-Amino-3-(4-imidazolyl)propionic acid;L -Histidine;NSC 137773
- CAS NO.：4998-57-6
- Empirical Formula: C6H9N3O2
- Molecular Weight: 155.15
- MDL number: MFCD00005208
- EINECS: 225-660-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-20 19:14:41
What is DL-Histidine?
Chemical properties
white to slightly yellow crystalline powder
The Uses of DL-Histidine
DL-Histidine has been used to study the fouling behaviour of polyethersulfone ultrafiltration membranes made with different PVP (polyvinylpyrrolidone).
The Uses of DL-Histidine
histidine is a skin-conditioning amino acid.
Definition
ChEBI: An alpha-amino acid that is propanoic acid bearing an amino substituent at position 2 and a 1H-imidazol-4-yl group at position 3.
Synthesis Reference(s)
Journal of the American Chemical Society, 67, p. 502, 1945 DOI: 10.1021/ja01219a513
Chemical and Pharmaceutical Bulletin, 35, p. 3447, 1987
Biochem/physiol Actions
L-Histidine is involved in the one-carbon unit metabolism. It is associated with protein methylation. L-Histidine is a part of hemoglobin structure and function. L-Histidine is a component of dipeptides with antioxidative property. Histidine serves as a precursor for the formation of histamine, which is associated with allergic responses. Urocanic acid, an immune response modulator in skin is also biosynthesised from histidine.
Properties of DL-Histidine
| Melting point: | 273 °C (dec.)(lit.) |
| Boiling point: | 278.95°C (rough estimate) |
| Density | 1.3092 (rough estimate) |
| refractive index | 1.6500 (estimate) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | 0.5 M HCl: soluble |
| form | powder to crystal |
| pka | 1.8(at 25℃) |
| color | White to Almost white |
| Merck | 14,4720 |
| BRN | 7800 |
| CAS DataBase Reference | 4998-57-6(CAS DataBase Reference) |
| EPA Substance Registry System | Histidine (4998-57-6) |
Safety information for DL-Histidine
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for DL-Histidine
New Products
DL-beta-(3-Bromophenyl)alanine Tetrabutylammonium perchlorate N,O-Dimethylhydroxylamine hydrochloride (RS)-beta-Amino-beta-(4-bromophenyl)propionic acid 2-Amino-5-bromo-4-(trifluoromethyl)pyridine（RM for Indian lab) N,N CARBONYL DIIMIDAZOLE Levothyroxine Impurity-F Montelukast EP Impurity-D/Montelukast USP Related Compound C Atorvastatin FXA Impurity/Atorvastatin Cyclic 6-Hydroxy Impurity Sodium Salt Isosulfan blue Keto N-Oxide Impurity Ivermectin Impurity F N-Nitroso des Methyl Tramadol/N-Nitroso-N-Desmethyl-Tramadol (R)-BoroLeu-(+)-Pinanediol-CF3COOH 1,4-bis(methylsulfonyl)butane 4-(5-amino-1-methyl-1h-benzoimidazol-2-yl)-butyric acid isopropyl ester. 5-Methyl-1,3-benzenediacetonitrile 4-Fluorothiophenol 1-methyl amino-2,4-dinitro benzene CSA (DL-10-Camphorsulfonic Acid) 2-Hydroxy-4-methylnicotinic acid 3-iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine (2S)-1-((2S,3S)-3-(2-methylbutyl)-4-oxooxetan-2-yl)pentadecan-2-yl formylleucinate 1-(3,5-dichlorophenyl)-2,2,2-trifluoroethane-1-sulfonyl chloride S-(1-(3,5-dichlorophenyl)-2,2,2-trifluoroethyl) ethanethioateRelated products of tetrahydrofuran
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