DISIALOGANGLIOSIDE GD1B 2NA
Synonym(s):Ganglioside GD1b, disialo
- CAS NO.：19553-76-5
- Empirical Formula: C84H148N4O40
- Molecular Weight: 1854.08
- MDL number: MFCD00466941
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-04-24 14:59:00
What is DISIALOGANGLIOSIDE GD1B 2NA?
Description
Ganglioside GD1b is an acidic glycosphingolipid that contains two sialic acid residues linked to an inner galactose unit. It is a component of plasma membranes where it packs densely with cholesterol to form lipid microdomains that modulate both intra- and intercellular signaling events. The concentration of ganglioside GD1b in human brain increases with age, constituting 7.85% of total sialic acid in the brain of 0- to 10-year-old subjects and 20.29% in 11- to 30-year-old subjects. Ganglioside GD1b levels are positively correlated with pilocytic astrocytoma tumor grade, and GD1b has been detected in various other gliomas, including primitive neuroectodermal tumors, glioblastomas, and anaplastic astrocytomas. Ganglioside GD1b mixture contains ganglioside GD1b molecular species with C18:1 and C20:1 fatty acyl chains.
The Uses of DISIALOGANGLIOSIDE GD1B 2NA
Ganglioside GD1b Disodium Salt (Bovine Brain) is a ganglioside, major constituents of neuronal cell membranes and endoplasmic reticulum that have been shown to modulate cell signal transduction.
What are the applications of Application
Ganglioside GD1b disodium salt is a ganglioside
General Description
Gangliosides are major constituents of neuronal cell membranes and endoplasmic reticulum; contain a sialated polysaccharide chain linked to ceramide through a β-glycosidic linkage; for classification of gangliosides see Svennerholm, L., et al. (eds.), Structure and Function of Gangliosides, New York, Plenum, 1980.
Biochem/physiol Actions
May act as a bacterial toxin receptor (tetanus, botulinus); high levels found in gliomas and astrocytomas.
Properties of DISIALOGANGLIOSIDE GD1B 2NA
| storage temp. | −20°C |
| solubility | Chloroform:Methanol:DI Water (2:1:0.1): soluble |
| form | lyophilized powder |
Safety information for DISIALOGANGLIOSIDE GD1B 2NA
Computed Descriptors for DISIALOGANGLIOSIDE GD1B 2NA
New Products
2-(2-Ethoxyphenoxy)ethyl bromide 1,3-Dibromo-2,2-dimethoxypropane 8-Bromo-7-(2-butynyl)-3-methyl xanthine 5-Chlorothiophene-2-carboxylic acid 8-Bromo-3-methyl xanthine Maleic hydrazide o-Anisaldehyde 4-Bromobenzaldehyde 3-Fluorobenzaldehyde 2-Chlorobenzaldehyde 3-Amino-3-(3-fluorophenyl)propanoic acid 1-Propyl-4-piperidone 2,3-Dihydro-5,6-dimethoxy-2-(4-piperidinylmethyl)-1H-inden-1-one hydrochloride 3-(4-Bromo-3-methyl-2-oxo-2,3-dihydro-1h-benzo[d]imidazol-1-yl)piperidine-2,6-dione 2-Fluoro-6-iodobenzoic acid 3-Pyridineacrylic acid 1-Boc-4-cyanopiperidine ethyl 2-oxo-2,3,9,10-tetrahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline-8(7H)-carboxylate Vardenafil Bis-sulphonamide(Dimer) Nitroso Irbesartan N-Nitroso Nortriptyline Sulfonic acid Impurity 2-(p-Tolyl)acetaldehyde 2,2-dibromo-1-cyclopropyl-2-(2-fluorophenyl)ethan-1-oneRelated products of tetrahydrofuran
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