Dimethyldioctadecylammonium bromide
Synonym(s):Dimethyldioctadecylammonium (Bromide Salt);Distearyldimethylammonium bromide
- CAS NO.：3700-67-2
- Empirical Formula: C38H80BrN
- Molecular Weight: 630.95
- MDL number: MFCD00041975
- EINECS: 223-037-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-08-21 22:16:43
What is Dimethyldioctadecylammonium bromide?
Description
18:0 DDAB is a double-chained quaternary ammonium surfactant with a bromide counter ion.
Chemical properties
white powder
The Uses of Dimethyldioctadecylammonium bromide
Dimethyldioctadecylammonium bromide has been used in a study to assess the interaction of its monolayers with DNA using specular neutron reflection, surface pressure-area isotherms, and Brewster angle microscopy. It has also been used in a study to investigate new adjuvants for use in kill vaccines for bovine viral diarrhea virus (BVDV).
General Description
18:0 DDAB is cationic lipid and a quaternary ammonium salt. The hydrocarbon tails are saturated unlike the ionizable lipids.
Biochem/physiol Actions
18:0 DDAB is a surface-active molecule, used as an adjuvant to induce systemic immune response. It is non-toxic.
Purification Methods
Crystallise the bromide from acetone, then MeOH [Lukac J Am Chem Soc 106 4387 1984]. Also purify it by chromatography on alumina by washing with *C6H6 and eluting with Me2CO, evaporating and crystallising from MeCN [Swain & Kreevoy J Am Chem Soc 77 1126 1955]. [Beilstein 4 IV 829.]
Properties of Dimethyldioctadecylammonium bromide
| Melting point: | ~160 °C |
| Density | 1.047 |
| RTECS | RG0185984 |
| refractive index | 1.5260 (estimate) |
| storage temp. | -20°C |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly, Heated), Hexanes (Slightly, Heat |
| form | Granular Powder |
| color | White |
| BRN | 3580323 |
| Stability: | Stable. Incompatible with strong oxidizing agents. |
| CAS DataBase Reference | 3700-67-2(CAS DataBase Reference) |
| EPA Substance Registry System | 1-Octadecanaminium, N,N-dimethyl-N-octadecyl-, bromide (3700-67-2) |
Safety information for Dimethyldioctadecylammonium bromide
| Signal word | Danger |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06  Health Hazard GHS08 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H331:Acute toxicity,inhalation H336:Specific target organ toxicity,single exposure; Narcotic effects H351:Carcinogenicity H372:Specific target organ toxicity, repeated exposure H412:Hazardous to the aquatic environment, long-term hazard |
| Precautionary Statement Codes |
P201:Obtain special instructions before use. P273:Avoid release to the environment. P302+P352:IF ON SKIN: wash with plenty of soap and water. P308+P313:IF exposed or concerned: Get medical advice/attention. |
Computed Descriptors for Dimethyldioctadecylammonium bromide
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