Dimethyl acetylsuccinate
Synonym(s):2-Acetylbutanedioic acid-1,4-dimethyl ester
- CAS NO.：10420-33-4
- Empirical Formula: C8H12O5
- Molecular Weight: 188.18
- MDL number: MFCD00008448
- EINECS: 233-897-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:13:04
What is Dimethyl acetylsuccinate?
The Uses of Dimethyl acetylsuccinate
Dimethyl Acetylsuccinate was used in preparation of β-carbolines via diastereo- and enantioselective Bronsted acid catalyzed N-acyliminium cyclization cascades of tryptamines and keto acids/esters.
The Uses of Dimethyl acetylsuccinate
Dimethyl acetylsuccinate has been used in the synthesis of 2-oxofuro[2,3-b]pyrroles and 19-methyl-15-oxa-20-azatricyclo[12.3.3.0(1,14)]icos-18-en-18-carboxylates.
General Description
Dimethyl acetylsuccinate undergoes sulfuric acid catalyzed Pechmann condensation with the corresponding resorcinol derivative to give 7-hydroxycoumarins.
Properties of Dimethyl acetylsuccinate
| Melting point: | 33 °C (lit.) |
| Boiling point: | 129-134 °C/12 mmHg (lit.) |
| Density | 1.16 g/mL at 25 °C (lit.) |
| vapor pressure | 19.6Pa at 25℃ |
| Flash point: | >230 °F |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | 30g/l OECD Test Guideline 105 |
| form | Notspecified |
| pka | 10.53±0.59(Predicted) |
| color | White or Colorless to Almost white or Almost colorless |
| explosive limit | 0.72-11.1%(V) |
| CAS DataBase Reference | 10420-33-4(CAS DataBase Reference) |
| EPA Substance Registry System | Butanedioic acid, acetyl-, dimethyl ester (10420-33-4) |
Safety information for Dimethyl acetylsuccinate
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Dimethyl acetylsuccinate
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