Diglycolic acid
Synonym(s):2,2′-Oxydiacetic acid
- CAS NO.：110-99-6
- Empirical Formula: C4H6O5
- Molecular Weight: 134.09
- MDL number: MFCD00004309
- EINECS: 203-823-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-04-24 14:58:11
What is Diglycolic acid?
Chemical properties
white to light beige crystalline powder
The Uses of Diglycolic acid
Diglycolic acid was used in the preparation of needle-like aragonite particles from calcium nitrate aqueous solutions.
Definition
ChEBI: Diglycolic acid is a dicarboxylic acid.
General Description
Diglycolic acid is a toxic metabolite of diethylene glycol (DEG) responsible for DEG-induced proximal tubular necrosis.
Biochem/physiol Actions
Diglycolic acid has antithrombogenic properties and induces vasodilation. It inhibits succinate dehydrogenase activity in human proximal tubule cells.
Safety Profile
Moderately toxic by ingestion. When heated to decomposition it emits acrid smoke and irritating vapors.
Purification Methods
Crystallise diglycolic acid from water. [Beilstein 3 IV 577.]
Properties of Diglycolic acid
| Melting point: | 140-144 °C (lit.) |
| Boiling point: | 167.16°C (rough estimate) |
| Density | 1.486 |
| refractive index | 1.4000 (estimate) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | ethanol: soluble5%, clear to slightly hazy, colorless to greenish-yellow |
| pka | pK1:2.96 (25°C) |
| form | Crystalline Powder |
| color | White to light beige |
| Water Solubility | Soluble |
| BRN | 1072117 |
| CAS DataBase Reference | 110-99-6(CAS DataBase Reference) |
| NIST Chemistry Reference | Diglycolic acid(110-99-6) |
| EPA Substance Registry System | Acetic acid, 2,2'-oxybis- (110-99-6) |
Safety information for Diglycolic acid
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral |
Computed Descriptors for Diglycolic acid
| InChIKey | QEVGZEDELICMKH-UHFFFAOYSA-N |
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