DICHLOROPHENYL-ABA

CAS NO.：18201-65-5
Empirical Formula: C13H9Cl2NO2
Molecular Weight: 282.12
MDL number: MFCD07370135
SAFETY DATA SHEET (SDS)
Update Date: 2026-04-23 15:06:17

What is DICHLOROPHENYL-ABA?

Biological Activity

Dichlorophenyl-ABA is an inhibitor of transthyretin (TTR) amyloid fibril formation and inhibits aggregate formation by more than 80% in cells expressing TTR L55P.

in vitro

Dichlorophenyl-ABA (DCPA) is able to prevent L55P aggregate formation in the conditioned medium. With regard to the ultrastructural analysis, Dichlorophenyl-ABA does not show an inhibitory effect as high as DFPB and benzoxazole, indicating that the Y78F mutant may not be as sensitive to this drug as TTR L55P and V30M are.
It is the best stabilizers of V30M tetramers in plasma from carriers of this mutant, and clearly inhibit aggregation in the cellular system. Therefore Dichlorophenyl-ABA -ABA is promising for the treatment of valine at position 30 (V30M)-associated familial amyloidotic polyneuropathy (FAP) but need to undergo further stages of drug development to overcome their toxicity.

Properties of DICHLOROPHENYL-ABA

Melting point:	245 °C
Boiling point:	420.8±45.0 °C(Predicted)
Density	1.470±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO: ~18 mg/mL at ~60 °C
form	solid
pka	3.62±0.36(Predicted)
color	white

Safety information for DICHLOROPHENYL-ABA

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for DICHLOROPHENYL-ABA

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