Dehydroevodiamine
- CAS NO.：67909-49-3
- Empirical Formula: C19H15N3O
- Molecular Weight: 301.35
- MDL number: MFCD11656140
- EINECS: 200-258-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-12-05 14:33:18
What is Dehydroevodiamine?
Chemical properties
White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from dried near-ripe fruit of Evodia sclerosus.
The Uses of Dehydroevodiamine
Dehydroevodiamine is a novel alkaloid which displays butyrylcholinesterase inhibitory activity in vivo.
Biological Activity
Dehydroevodiamine, a quinazoline alkaloid isolated from Evodiae Fructus, has antiarrhythmic effects on guinea pig ventricular myocytes. It inhibits LPS-induced expression of iNOS, COX-2, PGE2 and NF-κB in mouse macrophages.
Physiological effects
Dehydroevodiamine has an antihypertensive and antitumor effects.
in vitro
Dehydroevodiamine (0-50 μM; 2 hours) inhibits iNOS and COX-2 expression and prevents degradation of IκB-α in LPS induced RAW 264.7 macrophages. Dehydroevodiamine (0-50 μM; 2 hours) inhibits a LPS -induced increase in the iNOS and COX-2 mRNA expression.
Western Blot Analysis
| Cell Line: td> | RAW 264.7 macrophage cells |
| Concentration: | 10 μM, 30 μM, 50 μM |
| Incubation Time: | pretreated 2 hours |
| Result: | Reduced iNOS and COX-2 expression and increased IκB-α expression. |
RT-PCR
| RAW 264.7 macrophage cells | |
| Concentration: | 10 μM, 30 μM, 50 μM | td>
| Incubation Time: | pretreated 2 hours |
| Result: | Reduced iNOS and COX-2 mRNA expression. |
Properties of Dehydroevodiamine
| Melting point: | 190-192℃ |
| storage temp. | 2-8°C |
| solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. |
| form | powder |
| color | Yellow |
Safety information for Dehydroevodiamine
Computed Descriptors for Dehydroevodiamine
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