Dehydrocorydaline chloride
- CAS NO.：10605-03-5
- Empirical Formula: C22H24ClNO4
- Molecular Weight: 401.88326
- MDL number: MFCD01937870
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-04-21 10:31:43
What is Dehydrocorydaline chloride?
Biological Activity
Dehydrocorydaline chloride (13-Methylpalmatine chloride) is an alkaloid isolated from the traditional Chinese medicine Corydalis yanhusuo. It regulates Bax, Bcl-2 protein expression; activates caspase-7, caspase-8, and inactivates PARP. Also Dehydrocorydaline chloride can enhance the activation of p38 MAPK and has anti-inflammatory and anti-cancer effects. .
in vitro
Dehydrocorydaline significantly inhibits MCF-7 cell proliferation in a dose-dependent manner, which can be reversed by a caspase-8 inhibitor, Z-IETD-FMK. Dehydrocorydaline increases DNA fragments without affecting ΔΨm. Western blotting assay shows that dehydrocorydaline dose-dependently increases Bax protein expression and decreases Bcl-2 protein expression.
in vivo
Dehydrocorydaline (3.6, 6 or 10 mg/kg, ip) shows a dose-dependent anticiceptive effect in the acetic acid-induced writhing test and significantly attenuates the formalin-induced pain responses in mice. In the formalin test , dehydrocorydaline decreases the expression of caspase 6 (CASP6), TNF-α, IL-1β and IL-6 proteins in the spinal cord. These findings confirm that Dehydrocorydaline has antinociceptive effects in mice.
Properties of Dehydrocorydaline chloride
| Melting point: | 191-193 °C (decomp) |
| storage temp. | Store at -20°C |
| solubility | DMSO: 20 mg/ml |
| form | A solid |
| color | Light yellow to yellow |
Safety information for Dehydrocorydaline chloride
| Signal word | Danger |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06 |
| GHS Hazard Statements |
H301:Acute toxicity,oral H316:Skin corrosion/irritation |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P405:Store locked up. P501:Dispose of contents/container to..… |
Computed Descriptors for Dehydrocorydaline chloride
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