dBET1
- CAS NO.：1799711-21-9
- Empirical Formula: C38H37ClN8O7S
- Molecular Weight: 785.27
- MDL number: MFCD31544503
- Update Date: 2025-10-29 15:43:00
What is dBET1?
Description
dBET1 is a PROTAC compound comprised of BET bromodomain antagonist (+)-JQ1 linked to a cereblon E3 ubiquitin ligase ligand.
The Uses of dBET1
dBET1 induces highly selective cereblon-dependent BET protein degradation in vitro and in vivo as well as delays leukemia progression in mice.
Storage
Store at -20°C
Properties of dBET1
| Melting point: | 186 - 187°C |
| Density | 1.55±0.1 g/cm3(Predicted) |
| storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 10.68±0.40(Predicted) |
| color | Pale Yellow |
| Stability: | Hygroscopic |
Safety information for dBET1
Computed Descriptors for dBET1
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