DANSYL ETHYLENEDIAMINE
Synonym(s):N-(2-Aminoethyl)-5-dimethylamino-1-naphthalenesulfonamide;N-(2-Aminoethyl)dansylamide;DNSEDA;NSC 666752
- CAS NO.：35060-08-3
- Empirical Formula: C14H19N3O2S
- Molecular Weight: 293.38
- MDL number: MFCD00467523
- EINECS: 233-305-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-08-11 15:28:25
What is DANSYL ETHYLENEDIAMINE?
Description
Dansyl ethylenediamine is a lipophilic fluorophore that can be coupled to coarboxylic acids of proteins and other water-soluble polymers. The primary aliphatic amine of dansyl ethylenediamine can be reversibly coupled to aldehydes and ketones to form a Schiff base, which can be reduced to a generate stable amine derivative by sodium borohydride (NaBH4) or sodium cyanoborohydride (NaCNH3). Spectral data: λex=335nm, λem=525nm in methanol. Dansyl ethylenediamine has also shown to inhibit human renal dipeptidase (hrDP) irreversibly in a time-dependent manner.
Chemical properties
Yellow to orange powder.
The Uses of DANSYL ETHYLENEDIAMINE
A fluorescent reagent
The Uses of DANSYL ETHYLENEDIAMINE
A fluorescent reagent.
References
[1] YUKI INOUE. Fluorescent molecularly imprinted polymer thin films for specific protein detection prepared with dansyl ethylenediamine-conjugated O-acryloyl l-hydroxyproline[J]. Biosensors and Bioelectronics, 2013. DOI:10.1016/j.bios.2013.03.005.
[2] ADACHIH. Importance of Glu-125 in the catalytic activity of human renal dipeptidase.[J]. Biochimica et biophysica acta, 1993. DOI:10.1016/0167-4838(93)90276-w.
[3] MALLAMPATI S, AERSCHOT A V, HOOGMARTENS J, et al. Analysis of dideoxyadenosine triphosphate by CE with fluorescence detection. I. Derivatization through the phosphate group[J]. ELECTROPHORESIS, 2007, 28. DOI:10.1002/elps.200700234.
[4] DUDLEY R W, SLOTTERBECK B D, MCINERNEY M F, et al. Fatty acylation enhances cellular localization of dansylated phenylalanines[J]. Molecular and Cellular Biochemistry, 2010, 346: 81-87. DOI:10.1007/s11010-010-0593-4.
Properties of DANSYL ETHYLENEDIAMINE
| Melting point: | 145-146°C |
| Boiling point: | 470.2±55.0 °C(Predicted) |
| Density | 1.262±0.06 g/cm3(Predicted) |
| storage temp. | -20°C Freezer |
| solubility | methanol: soluble1mg/mL, clear, slightly yellow to deep yellow |
| form | Solid |
| pka | 11.30±0.50(Predicted) |
| color | Light Yellow |
| BRN | 2817535 |
Safety information for DANSYL ETHYLENEDIAMINE
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for DANSYL ETHYLENEDIAMINE
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