Dalbavancin hydrochloride

CAS NO.：2227366-51-8
Empirical Formula: C88H101Cl3N10O28
Molecular Weight: 1853.17
MDL number: MFCD32173458
Update Date: 2026-07-16 07:06:08

What is Dalbavancin hydrochloride?

Biological Activity

Dalbavancin hydrochloride(MDL-63397 hydrochloride) is a semi-synthetic lipoglycopeptide antibiotic with potent bactericidal activity against Gram-positive bacteria. Dalbavancin hydrochloride inhibits Staphylococcus aureus and Bacillus anthracis with MIC90 of 0.06 μg/mL and 0.25 μg/mL, respectively.

in vitro

Dalbavancin is a parenterally administered semisynthetic lipoglycopeptide developed to combat infections caused by resistant gram-positive pathogens. Dalbavancin exhibits potent in vitro bactericidal activity against gram-positive pathogens including S. aureus (MRSA ), VISA, and non-VanA strains of VRE. Dalbavancin is developed for the treatment of complicated skin and skin structure infections (cSSSIs), predominantly those caused by MRSA and β-hemolytic streptococci , organisms against which it has shown greater potency than existing glycopeptide therapeutic agents.

in vivo

Dalbavancin (15-240 mg/kg; intraperitoneal injection; every 36 h or 72 h; for 14 days; female BALB/c mice) treatment has a survival rate of 80% to 100% of mice with all dose regimens.

Animal Model:	Female BALB/c mice (6-8 weeks) challenged with Ames strain of B . anthracis
Dosage:	15 mg/kg, 30 mg/kg, 60 mg/kg, 120 mg/kg, 240 mg/kg
Administration:	Intraperitoneal injection ; every 36 h or 72 h; for 14 days
Result:	The efficacy was 80 to 100%, as determined by the rate of survival at 42 days, when treatment was initiated 24 h postchallenge with regimens of 15 to 120 mg/kg every 36 h or 30 to 240 mg/kg every 72 h.

Properties of Dalbavancin hydrochloride

storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	DMSO: ≥ 24 mg/mL (12.95 mM)
form	Solid
color	White to light yellow
Water Solubility	Water: 50 mg/mL (26.98 mM)

Safety information for Dalbavancin hydrochloride

Computed Descriptors for Dalbavancin hydrochloride

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