D-2-Phenylglycine
Synonym(s):(R)-(−)-2-Phenylglycine;D -2-Phenylglycine;R-(−)-α-Aminophenylacetic acid
- CAS NO.：875-74-1
- Empirical Formula: C8H9NO2
- Molecular Weight: 151.16
- MDL number: MFCD00008061
- EINECS: 212-876-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-04-24 14:58:46
What is D-2-Phenylglycine?
Description
d-Phenylglycine is widely used in large quantity as the side chain that makes ampicillin and cephalexin orally acceptable.
Chemical properties
White crystalline powder
The Uses of D-2-Phenylglycine
D-(-)-2-Phenylglycine is the derivative of glycine (G615990), a non-essential amino acid for human development. Glycine is an inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA r eceptors.
The Uses of D-2-Phenylglycine
D-(-)-2-Phenylglycine (Cefalexin EP Impurity A) is the derivative of glycine (G615990), a non-essential amino acid for human development. Glycine is an inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.
Definition
ChEBI: The R stereoisomer of alpha-phenylglycine.
Flammability and Explosibility
Non flammable
Synthesis
Industrially, dphenylglycine
has been produced by a conventional
resolution method or by kinetic resolution
with acylase. Another enzymatic procedure has
been developed by Yamada et al. ,
as shown below.
Properties of D-2-Phenylglycine
| Melting point: | 302 °C (dec.)(lit.) |
| Boiling point: | 273.17°C (rough estimate) |
| alpha | -156 º (c=1,1N HCl) |
| Density | 1.2 g/cm3 (20℃) |
| vapor pressure | 0Pa at 25℃ |
| refractive index | -158 ° (C=1, 1mol/L HCl) |
| Flash point: | 150 °C |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | Aqueous Acid (Sparingly), Water (Slightly, Heated) |
| form | Crystalline Powder |
| pka | 1.94±0.10(Predicted) |
| color | White |
| optical activity | [α]20/D 155°, c = 1 in 1 M HCl |
| Water Solubility | 0.3g/100mL |
| Merck | 14,7291 |
| BRN | 2208676 |
| CAS DataBase Reference | 875-74-1(CAS DataBase Reference) |
| NIST Chemistry Reference | d a-Phenylglycine(875-74-1) |
| EPA Substance Registry System | Benzeneacetic acid, .alpha.-amino-, (.alpha.R)- (875-74-1) |
Safety information for D-2-Phenylglycine
Computed Descriptors for D-2-Phenylglycine
D-2-Phenylglycine manufacturer
Chemfield Inc
ASM Organics
New Products
2-Ethoxyphenol Methyl 2-methoxy-5-sulfamoylbenzoate 3,6-Dichloropyridazine Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate 3,6-Dichloro-4-Isopropylpyridazine 2-[(2-Ethoxyphenoxy)methyl]oxirane 4-Morpholinoaniline 2-Chloromethyl-6-methyl-pyridine 1-Indanone tert-Butyl ((1R,2S,5S)-2-amino-5-(dimethylcarbamoyl)cyclohexyl)carbamate 2-Pyridinecarboxaldehdye 6-Methyl-2-pyridinemethanol 4-Bromo-2-fluoro-N-methylbenzamide 3-Azetidinecarboxylic acid N-(2-(4-((4-Fluorobenzyl)carbamoyl)-5-hydroxy-6-methoxypyrimidin-2-yl)propan-2-yl)-5-methyl-1,3,4-oxadiazole-2-carboxamide (R)-4-Boc-morpholine-3-carboxylic acid (Required high chiral purity NLT:99.5%) Tetrahydro-3-(2-methyl-2- nitropropyl)-2H-pyran-2-one 3-Bromo-2-fluorobenzonitrile Desoximetasone Boron Triiodide Nicotinic acid RAPAMYCIN Pentachlorobenzonitrile BudesonideRelated products of tetrahydrofuran
![(6R-trans)-7-[(2,2-diMethyl-1-oxopropyl)aMino]-3-Methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-](https://img.chemicalbook.in/CAS/GIF/146794-70-9.gif)
You may like
-
875-74-1 Cefaclor EP Impurity A 99%View Details
875-74-1 -
D-alpha-Phenylglycine 99%View Details -
D-2-Phenylglycine 98% CAS 875-74-1View Details
875-74-1 -
D-2-Phenylglycine CAS 875-74-1View Details
875-74-1 -
D(-)-alpha-Phenylglycine 99% (HPLC) CAS 875-74-1View Details
875-74-1 -
D-Phenylglycine, 99% CAS 875-74-1View Details
875-74-1 -
D−(−)-α-Phenylglycine CAS 875-74-1View Details
875-74-1 -
D-Phenylglycine, For IndustrialView Details
875-74-1