CZC-54252
- CAS NO.：1191911-27-9
- Empirical Formula: C22H25ClN6O4S
- Molecular Weight: 504.99
- MDL number: MFCD26401527
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-07-14 16:49:18
What is CZC-54252?
The Uses of CZC-54252
CZC 54252 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2). LRRK2 mutations are associated with familial Parkinson''s disease and a potential therapeutic target.
Definition
ChEBI: CZC-25146 is a member of the class of aminopyrimidines that is 2,6-diamino-5-chloropyrimidine in which the amino groups at positions 2 and 6 are respectively carrying 2-methoxy-4-(morpholin-4-yl)phenyl and 2-(methanesulfonylamino)phenyl substituents. It is an inhibitor of the Parkinson's disease kinase LRRK2. It has a role as an EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor. It is an aminopyrimidine, a member of morpholines, an aromatic ether, an organochlorine compound, a sulfonamide and a secondary amino compound.
Properties of CZC-54252
| Boiling point: | 718.1±70.0 °C(Predicted) |
| Density | 1.452±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| solubility | DMF: 20 mg/mL; DMF:PBS(pH 7.2)(1:1): 0.5 mg/mL; DMSO: 10 mg/mL |
| form | Powder |
| pka | 8.50±0.10(Predicted) |
| color | White to off-white |
Safety information for CZC-54252
Computed Descriptors for CZC-54252
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![N-{2-[(5-chloro-2-{[2-methoxy-4-(morpholin-4-yl)phenyl]amino}pyrimidin-4-yl)amino]phenyl}methanesulfonamide 95% CAS 1191911-27-9](https://img.chemicalbook.in//Content/image/CP5.jpg)
N-{2-[(5-chloro-2-{[2-methoxy-4-(morpholin-4-yl)phenyl]amino}pyrimidin-4-yl)amino]phenyl}methanesulfonamide 95% CAS 1191911-27-9View Details
1191911-27-9 -
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