Cynaroside

Synonym(s):Cynaroside;Luteoloside;Glucoluteolin;Glucosylluteolin;Luteolin 7-O-β-D-glucoside

CAS NO.：5373-11-5
Empirical Formula: C21H20O11
Molecular Weight: 448.38
MDL number: MFCD06799436
EINECS: 226-365-8
SAFETY DATA SHEET (SDS)
Update Date: 2026-03-10 21:10:33

What is Cynaroside?

Description

Luteolin-7-O-glucoside is a flavonoid that has been found in many Chinese herbs with diverse biological activities. It reduces lactate dehydrogenase (LDH) and caspase-3 activities and production of reactive oxygen species (ROS) and increases cell viability and 14-3-3η protein levels in H9C2 cardiomyocytes after anoxia/reoxygenation injury. Luteoloside blocks 3C protease activity (IC₅₀ = 0.36 mM) and reduces the cytopathic effect of enterovirus 71 in rhabdomyosarcoma cells (EC₅₀ = 0.43 mM). It inhibits the growth of hepatocellular carcinoma (HCC) cells in vitro via reduction in ROS accumulation, caspase-1 activity, and expression of the NLRP3 inflammasome and reduces the number of lung metastases in an SMMC-7721 HCC mouse xenograft model when administered at a dose of 2 mg/kg. Luteoloside also reduces acanthosis and expression of epidermal differentiation markers in a mouse model of psoriasis induced by imiquimod .

Chemical properties

Off-white powder

The Uses of Cynaroside

Luteolin 7-Glucoside is a strong antioxidant ant radical scavenger. Used in cancer prevention.

What are the applications of Application

Luteolin-7-O-D-glucopyranoside is a flavenoid

Definition

ChEBI: A glycosyloxyflavone that is luteolin substituted by a beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage.

Properties of Cynaroside

Melting point:	256～258℃
storage temp.	Sealed in dry,2-8°C
solubility	DMSO (Slightly), Methanol (Slightly)
Boiling point:	838.1±65.0 °C(Predicted)
Density	1.713±0.06 g/cm3(Predicted)
form	neat
pka	6.10±0.40(Predicted)
form	Solid
color	Yellow to Very Dark Yellow
Stability:	Hygroscopic
CAS DataBase Reference	5373-11-5(CAS DataBase Reference)