Cyclopropylacetylene
Synonym(s):Ethynylcyclopropane
- CAS NO.：6746-94-7
- Empirical Formula: C5H6
- Molecular Weight: 66.1
- MDL number: MFCD02181090
- EINECS: 425-430-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:16:20
What is Cyclopropylacetylene?
Preparation
Cyclopropylacetylene was prepared in a two-step procedure by dichlorination of cyclopropyl methyl ketone with phosphorus pentachloride (PCl5) followed by double dehydrohalogenation with a strong base. This sequence presented significant scale-up problems with low overall yields (20-25%).
Similarly, cyclopropylacetylene has been prepared by base-induced dehydrohalogenation of bromovinylcyclopropane . Cyclopropylacetylene has also been prepared from the 1-trimethylsilyl derivative of cyclopropylacetylene, which was prepared by treatment of 5-chloro-1-trimethylsilyl-1-pentyne with lithium diisopropylamide at ?78°C followed by warming to room temperature.
Chemical properties
clear colorless to light yellow liquid
The Uses of Cyclopropylacetylene
Cyclopropylacetylene is used as an organic chemical synthesis intermediate.
Properties of Cyclopropylacetylene
| Melting point: | 294 °C (decomp) |
| Boiling point: | 79-80 °C |
| Density | 0.7801 |
| refractive index | n |
| Flash point: | -5 °F |
| storage temp. | 2-8°C |
| solubility | Chloroform, Ethyl Acetate |
| form | Liquid |
| color | Clear colorless to light yellow |
| Specific Gravity | 0.797 |
| Water Solubility | Slightly soluble in water. |
| InChI | InChI=1S/C5H6/c1-2-5-3-4-5/h1,5H,3-4H2 |
| CAS DataBase Reference | 6746-94-7(CAS DataBase Reference) |
| NIST Chemistry Reference | Cyclopropylacetylene(6746-94-7) |
Safety information for Cyclopropylacetylene
| Signal word | Danger |
| Pictogram(s) |
 Flame Flammables GHS02  Corrosion Corrosives GHS05 |
| GHS Hazard Statements |
H225:Flammable liquids H315:Skin corrosion/irritation H318:Serious eye damage/eye irritation H412:Hazardous to the aquatic environment, long-term hazard |
| Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P233:Keep container tightly closed. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Cyclopropylacetylene
| InChIKey | NPTDXPDGUHAFKC-UHFFFAOYSA-N |
| SMILES | C1(C#C)CC1 |
Cyclopropylacetylene manufacturer
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