Cyclooctylamine
Synonym(s):Aminocyclooctane
- CAS NO.：5452-37-9
- Empirical Formula: C8H17N
- Molecular Weight: 127.23
- MDL number: MFCD00001748
- EINECS: 226-694-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:22:51
What is Cyclooctylamine?
Chemical properties
clear colorless to light yellow liquid
The Uses of Cyclooctylamine
Cyclooctylamine is used as pharmaceutical intermediates.
Production Methods
Cyclooctylamine can be produced by the Ritter reaction of cyclooctanol with hydrocyanic acid, by reduction of cyclooctanone oxime with sodium and an alcohol, by Ritter reaction of cyclooctene with hydrocyanic acid, or by catalytic hydrogenation of cyclooctanone under amination conditions.
Properties of Cyclooctylamine
| Melting point: | -48 °C (lit.) |
| Boiling point: | 190 °C (lit.) |
| Density | 0.928 g/mL at 25 °C (lit.) |
| refractive index | n |
| Flash point: | 145 °F |
| storage temp. | Store below +30°C. |
| solubility | 10.2g/l |
| form | Liquid |
| pka | 11.03±0.20(Predicted) |
| color | Clear colorless to light yellow |
| PH | 11.5 (4g/l, H2O, 20℃) |
| Water Solubility | Soluble in water. 10.2 g/L at 20°C. |
| BRN | 2689120 |
| CAS DataBase Reference | 5452-37-9(CAS DataBase Reference) |
| NIST Chemistry Reference | Cyclooctanamine(5452-37-9) |
| EPA Substance Registry System | Cyclooctanamine (5452-37-9) |
Safety information for Cyclooctylamine
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05 |
| GHS Hazard Statements |
H314:Skin corrosion/irritation |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P363:Wash contaminated clothing before reuse. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for Cyclooctylamine
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