CYCLO (ARG-GLY-ASP-D-PHE-LYS)

CAS NO.：161552-03-0
Empirical Formula: C27H41N9O7
Molecular Weight: 603.67
MDL number: MFCD00937400
SAFETY DATA SHEET (SDS)
Update Date: 2026-04-17 13:05:51

What is CYCLO (ARG-GLY-ASP-D-PHE-LYS)?

The Uses of CYCLO (ARG-GLY-ASP-D-PHE-LYS)

Cyclo (-RGDfK) Trifluoroacetic Acid Salt is a potent inhibitor of αvβ3 integrin. Used in tumor therapy due to the targeting of the VEGFR2 gene by sRNA.

Biological Activity

in one study where this peptide was labeled with 125i, it was found to bind specifically and with high affinity to αvβ3 receptors on neovascular blood vessel sections of different major human cancers. the integrin alpha(iib)beta(3)-specific cyclic hexapeptide contains an arg-gly-asp (rgd) sequence.

Properties of CYCLO (ARG-GLY-ASP-D-PHE-LYS)

Melting point:	191℃ (decomposition)
Density	1.47±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	≥30.19 mg/mL in DMSO; insoluble in EtOH; ≥59.2 mg/mL in H2O
form	Powder
pka	4.01±0.10(Predicted)
color	White to off-white

Safety information for CYCLO (ARG-GLY-ASP-D-PHE-LYS)

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for CYCLO (ARG-GLY-ASP-D-PHE-LYS)

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