colchiceine
- CAS NO.：477-27-0
- Empirical Formula: C21H23NO6
- Molecular Weight: 385.41
- EINECS: 207-512-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-04-21 10:31:43
What is colchiceine?
Description
Colchicine is obtained by extracting the seeds and/or corm of Colchicum autumnale Linn′e. Colchicine is a specific drug for the treatment of gouty arthritis. It is especially useful in acute attacks but also is used prophylactically in conjunction with other drugs, such as allopurinol or phenylbutazone. The drug is believed to act by disrupting microtubular assembly in inflammatory cells, thereby impairing both their locomotion and their membrane function, including phagocytosis and the release of inflammatory mediators. The alkaloid is extremely toxic and must be used with care. Gastrointestinal adverse effects include nausea, vomiting, and diarrhea. Blood disorders, including agranulocytosis and aplastic anemia, sometimes are seen after prolonged administration of this drug.
Chemical properties
Off- White to Pale Yellow Solid
The Uses of colchiceine
A metabolite of Colchicine
What are the applications of Application
Colchiceine is a metabolite of Colchicine
Background
Colchiceine is one of several metabolites of the anti-gout medication colchicine.
Definition
ChEBI: Colchiceine is a cyclic ketone.
Trade name
Colchicina (Smith Kline, Brazil), Colchicine (Various, USA), ColchicumDispert (Solvay, Poland), Colabid (Major, USA).
Metabolism
Not Available
Properties of colchiceine
| Melting point: | 172-1740C |
| Boiling point: | 511.86°C (rough estimate) |
| alpha | D25 -255.1° (c = 1 in chloroform) |
| Density | 1.2400 |
| refractive index | 1.5614 (estimate) |
| storage temp. | Refrigerator |
| solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
| pka | 7.59±0.40(Predicted) |
| form | Solid |
| color | Off-White to Pale Yellow |
Safety information for colchiceine
Computed Descriptors for colchiceine
New Products
2-(2-Ethoxyphenoxy)ethyl bromide 1,3-Dibromo-2,2-dimethoxypropane 8-Bromo-7-(2-butynyl)-3-methyl xanthine 5-Chlorothiophene-2-carboxylic acid 8-Bromo-3-methyl xanthine Maleic hydrazide o-Anisaldehyde 4-Bromobenzaldehyde 3-Fluorobenzaldehyde 2-Chlorobenzaldehyde 3-Amino-3-(3-fluorophenyl)propanoic acid 1-Propyl-4-piperidone 2,3-Dihydro-5,6-dimethoxy-2-(4-piperidinylmethyl)-1H-inden-1-one hydrochloride 3-(4-Bromo-3-methyl-2-oxo-2,3-dihydro-1h-benzo[d]imidazol-1-yl)piperidine-2,6-dione 2-Fluoro-6-iodobenzoic acid 3-Pyridineacrylic acid 1-Boc-4-cyanopiperidine ethyl 2-oxo-2,3,9,10-tetrahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline-8(7H)-carboxylate Vardenafil Bis-sulphonamide(Dimer) Nitroso Irbesartan N-Nitroso Nortriptyline Sulfonic acid Impurity 2-(p-Tolyl)acetaldehyde 2,2-dibromo-1-cyclopropyl-2-(2-fluorophenyl)ethan-1-oneRelated products of tetrahydrofuran
![[epicatechin-(4beta->8)]5-epicatechin](https://img.chemicalbook.in/CAS/20180906/GIF/88847-05-6.gif)
You may like
-
477-27-0 Colchicine EP Impurity F 95.8View Details
477-27-0 -
Deuterated Styrene-d8 19361-62-7 97-99%View Details
19361-62-7 -
1187989-89-4 97-99%View Details
1187989-89-4 -
(S)-2-Bromobutanoic acid 97-99%View Details
32659-49-7 -
665020-24-6 ethyl 1-(2,4-dichlorophenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxylate 97-99%View Details
665020-24-6 -
methyl 3-amino-4-formylbenzoate 97-99%View Details
212322-17-3 -
3-bromo-[1,1'-biphenyl]-2-amine 1620885-59-7 97-99%View Details
1620885-59-7 -
1503408-77-2 6-Chloro-3,4-dimethylpyridin-2-amine 97-99%View Details
1503408-77-2