colchiceine
- CAS NO.：477-27-0
- Empirical Formula: C21H23NO6
- Molecular Weight: 385.41
- EINECS: 207-512-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-12 16:37:52
What is colchiceine?
Description
Colchicine is obtained by extracting the seeds and/or corm of Colchicum autumnale Linn′e. Colchicine is a specific drug for the treatment of gouty arthritis. It is especially useful in acute attacks but also is used prophylactically in conjunction with other drugs, such as allopurinol or phenylbutazone. The drug is believed to act by disrupting microtubular assembly in inflammatory cells, thereby impairing both their locomotion and their membrane function, including phagocytosis and the release of inflammatory mediators. The alkaloid is extremely toxic and must be used with care. Gastrointestinal adverse effects include nausea, vomiting, and diarrhea. Blood disorders, including agranulocytosis and aplastic anemia, sometimes are seen after prolonged administration of this drug.
Chemical properties
Off- White to Pale Yellow Solid
The Uses of colchiceine
A metabolite of Colchicine
What are the applications of Application
Colchiceine is a metabolite of Colchicine
Background
Colchiceine is one of several metabolites of the anti-gout medication colchicine.
Definition
ChEBI: Colchiceine is a cyclic ketone.
Trade name
Colchicina (Smith Kline, Brazil), Colchicine (Various, USA), ColchicumDispert (Solvay, Poland), Colabid (Major, USA).
Metabolism
Not Available
Properties of colchiceine
| Melting point: | 172-1740C |
| Boiling point: | 511.86°C (rough estimate) |
| alpha | D25 -255.1° (c = 1 in chloroform) |
| Density | 1.2400 |
| refractive index | 1.5614 (estimate) |
| storage temp. | Refrigerator |
| solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
| pka | 7.59±0.40(Predicted) |
| form | Solid |
| color | Off-White to Pale Yellow |
Safety information for colchiceine
Computed Descriptors for colchiceine
New Products
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![[epicatechin-(4beta->8)]5-epicatechin](https://img.chemicalbook.in/CAS/20180906/GIF/88847-05-6.gif)
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