Clobetasone butyrate
Synonym(s):21-Chloro-9-fluoro-17-hydroxy-16-methylpregna-1,4-diene-3,11,20-trione 17-butyrate
- CAS NO.：25122-57-0
- Empirical Formula: C26H32ClFO5
- Molecular Weight: 478.98
- MDL number: MFCD00133196
- EINECS: 246-635-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-12-10 09:00:29
What is Clobetasone butyrate?
Chemical properties
White or almost white powder.
The Uses of Clobetasone butyrate
Glucocorticoid; anti-inflammmatory.
What are the applications of Application
Clobetasone butyrate is an antiinflammatory synthetic glucocorticoid
Definition
ChEBI: Clobetasone butyrate is an organic molecular entity.
Mechanism of action
Topical corticosteroids (Clobetasone butyrate) inhibit the migration of macrophages and leukocytes into areas of inflamed skin by reversing vascular dilation and permeability, resulting in decreased erythema, edema and pruritus.
Side Effects
Some people get a burning or stinging feeling for a few minutes when they put clobetasone cream or ointment on their skin. Clobetasone cream contains cetostearyl alcohol and chlorocresol, which may cause local skin reactions or allergic reactions.
Properties of Clobetasone butyrate
| Melting point: | 90-100° |
| Boiling point: | 573.3±50.0 °C(Predicted) |
| Density | 1.1736 (estimate) |
| storage temp. | Refrigerator, Under Inert Atmosphere |
| solubility | Practically insoluble in water, freely soluble in acetone and in methylene chloride, slightly soluble in ethanol (96 per cent). |
| form | neat |
| form | Solid |
| color | White to Off-White |
| Stability: | Stable. Combustible. Incompatible with strong oxidizing agents. |
| CAS DataBase Reference | 25122-57-0(CAS DataBase Reference) |
Safety information for Clobetasone butyrate
| Signal word | Warning |
| Pictogram(s) |
 Health Hazard GHS08 |
| GHS Hazard Statements |
H351:Carcinogenicity |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for Clobetasone butyrate
| InChIKey | FBRAWBYQGRLCEK-JGSYYNBSNA-N |
| SMILES | [C@]1(C(=O)CCl)(OC(=O)CCC)[C@@H](C)C[C@@]2([H])[C@]3([H])CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)C(=O)C[C@]12C |&1:0,11,14,16,26,28,33,r| |
Clobetasone butyrate manufacturer
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