Clasto-Lactacystin ?-lactone

Chemical properties

White Solid

The Uses of Clasto-Lactacystin ?-lactone

clasto-Lactacystin beta-lactone is a 20S proteasome and cathepsin A inhibitor.

The Uses of Clasto-Lactacystin ?-lactone

A cell permeable, irreversible proteasome inhibitor. It is 20-fold more potent than Lactacystin. Lactacytstin spontaneously converts to clasto-lactacystin in biological systems. Clasto-lactacystin is the only cell permeable form of lactacystin. Induces neurite growth and inhibits cell cycle progression similar to lactacytin.

The Uses of Clasto-Lactacystin ?-lactone

Clasto-Lactacystin β-lactone has been used as a proteasomal inhibitor.

What are the applications of Application

clasto-Lactacystin β-Lactone is an active species of lactacystin proteasome inhibition

Biological Activity

cell-permeable. a highly specific, potent and irreversible proteasome inhibitor. lactacystin (cat. no. 1709-200) acts as a precursor for clasto-lactacystin β-lactone and the latter compound is at least 10 times more active than the parent lactacystin

Biochem/physiol Actions

Clasto-Lactacystin β-lactone (cLβL) is synthesized from lactacystin. It is cell-permeable and cLβL acts on the N-terminal threonine of subunit proteasome β -subunit X It also inhibits 20S proteasome activity in Haloferax volcanii?by acting in the N-threonine residue of the? β -type subunits.