Cinobufotalin
Synonym(s):14,15β-Epoxy-3β,5α,16β-trihydroxy-5β,20(22)-bufadienolide 16-acetate;5β,20(22)-Bufadienolide-14,15β-epoxy-3β,5α,16β-triol 16-acetate
- CAS NO.：1108-68-5
- Empirical Formula: C26H34O7
- Molecular Weight: 458.54
- MDL number: MFCD28396383
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-04-22 18:57:36
What is Cinobufotalin?
Description
Cinobufacin is an indole-type total alkaloid extracted from the dried toad skin of Chinese toad, which has the functions of clearing away heat and detoxifying, reducing swelling and pain, promoting blood circulation and removing blood stasis, softening and dispelling knots.
What are the applications of Application
Cinobufotalin is a specific Na+/K+-ATPase inhibitor
What are the applications of Application
Cinobufacin can be used for a variety of middle and advanced tumors (lung cancer, breast cancer, cervical cancer, digestive system tumors such as primary liver cancer, gastric cancer, colon cancer, etc.), chronic hepatitis B, especially for chronic hepatitis B virus carriers. Especially prominent.
Side Effects
For individual patients, if the dosage is too large or the interval between two administrations is less than 6 to 8 hours, chills and fever may occur about 30 minutes after administration; a small number of patients have local irritation or phlebitis after long-term intravenous infusion, which will slow down the infusion rate. Very few patients may also appear urticaria, dermatitis and so on.
Properties of Cinobufotalin
| Melting point: | 259-262° |
| Boiling point: | 627.3±55.0 °C(Predicted) |
| alpha | D20 +11° |
| Density | 1.34±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMF: 10 mg/ml; DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml; DMSO: 5 mg/ml; Ethanol: 5 mg/ml |
| pka | 14.67±0.70(Predicted) |
| form | White to off-white solid. |
| color | White to off-white |
| CAS DataBase Reference | 1108-68-5 |
Safety information for Cinobufotalin
| Signal word | Danger |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06 |
| Precautionary Statement Codes |
P260:Do not breathe dust/fume/gas/mist/vapours/spray. P262:Do not get in eyes, on skin, or on clothing. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for Cinobufotalin
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