CD437
Synonym(s):6-(3-(1-Adamantyl)-4-hydroxyphenyl)-2-naphthalene carboxylic acid;6-[3-(1-Adamantyl)-4-hydroxyphenyl]-2-naphthalene carboxylic acid;AHPN;Apoptosis Activator VI, CD437/AHPN - CAS 125316-60-1 - Calbiochem
- CAS NO.：125316-60-1
- Empirical Formula: C27H26O3
- Molecular Weight: 398.49
- MDL number: MFCD03106506
- EINECS: 200-258-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-28 04:59:39
What is CD437?
Chemical properties
Yellow Solid
The Uses of CD437
An intermediate in the preparation of Adapalene derivatives.
What are the applications of Application
CD 437 is A cell-permeable retinoid-related molecule tumor growth arrest and apoptosis inducer
Definition
ChEBI: A naphthoic acid that is 6-phenylnaphthylene-2-carboxyic acid in which the phenyl substituent has been substituted at positions 3 and 4 by adamant-1-yl and hydroxy groups, respectively. It acts as a selective agonist of retinoic acid receptor (RAR)g mma and induces cell cycle arrest and apoptosis in various cancer cells.
Biological Activity
Synthetic retinoid that is an RAR γ -selective agonist. Displays RAR γ -dependent and -independent effects on differentiation and apoptosis.
Biochem/physiol Actions
CD437 is a retinoic acid receptor (RAR)γ-selective agonist, γ-selective retinoid; potent inducer of apoptosis.
Storage
Store at -20°C
Properties of CD437
| Melting point: | 271.6-276 °C |
| Boiling point: | 595.0±50.0 °C(Predicted) |
| Density | 1.290 |
| storage temp. | -20°C |
| solubility | DMSO: 26 mg/mL |
| form | solid |
| pka | 4.17±0.30(Predicted) |
| color | yellow |
Safety information for CD437
Computed Descriptors for CD437
New Products
Cis-Tosylate Dibenzoyl-L-tartaric acid Anhydrous (Resolution Reagent) 2,6-Dipicolic Acid 1,2,3,9-Tetrahydro-9-Methyl-4H-Carbazole-4-One Dibenzo[b,f][1,4]thiazepin-11(10H)-one N-BOC-piperidine-4-carboxylic acid 1-Benzhydrylazetane-3-carbonitrile AMINO-(3-CHLORO-PHENYL)-ACETIC ACID 2-(2-Chlorophenyl)glycine (±)-amino(2-fluorophenyl)acetic acid 8-oxa-1,3-diazaspiro[4.5]decane-2,4-dione MEHYL AMINE-D3.HCL METHANE SULFONIC ACID-D4 PHOSPORIC ACID-D3 85 W% IN D2O DEUTERIUM OXIDE FOR NMR TOLUENE-D3 BENZENE-D6 1-(3-Chlorophenyl)piperazine hydrochlorideRelated products of tetrahydrofuran
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