CD437
Synonym(s):6-(3-(1-Adamantyl)-4-hydroxyphenyl)-2-naphthalene carboxylic acid;6-[3-(1-Adamantyl)-4-hydroxyphenyl]-2-naphthalene carboxylic acid;AHPN;Apoptosis Activator VI, CD437/AHPN - CAS 125316-60-1 - Calbiochem
- CAS NO.：125316-60-1
- Empirical Formula: C27H26O3
- Molecular Weight: 398.49
- MDL number: MFCD03106506
- EINECS: 200-258-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-11 16:31:51
What is CD437?
Chemical properties
Yellow Solid
The Uses of CD437
An intermediate in the preparation of Adapalene derivatives.
What are the applications of Application
CD 437 is A cell-permeable retinoid-related molecule tumor growth arrest and apoptosis inducer
Definition
ChEBI: A naphthoic acid that is 6-phenylnaphthylene-2-carboxyic acid in which the phenyl substituent has been substituted at positions 3 and 4 by adamant-1-yl and hydroxy groups, respectively. It acts as a selective agonist of retinoic acid receptor (RAR)g mma and induces cell cycle arrest and apoptosis in various cancer cells.
Biological Activity
Synthetic retinoid that is an RAR γ -selective agonist. Displays RAR γ -dependent and -independent effects on differentiation and apoptosis.
Biochem/physiol Actions
CD437 is a retinoic acid receptor (RAR)γ-selective agonist, γ-selective retinoid; potent inducer of apoptosis.
Storage
Store at -20°C
Properties of CD437
| Melting point: | 271.6-276 °C |
| Boiling point: | 595.0±50.0 °C(Predicted) |
| Density | 1.290 |
| storage temp. | -20°C |
| solubility | DMSO: 26 mg/mL |
| form | solid |
| pka | 4.17±0.30(Predicted) |
| color | yellow |
Safety information for CD437
Computed Descriptors for CD437
New Products
Tridecanoic acid 3-Bromophenylacetic acid 3-AMINO-3-(2-FLUORO-PHENYL)-PROPIONIC ACID Hendecanoic acid 2-Amino-5-cyanopyridine 2-Bromo-5-cyanopyridine 4-(4-(Dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl)-3-(hydroxymethyl)benzonitrile 5-Bromo-4-chloro-3-indolyl-β-D-galactopyranoside Tetracaine Hydrochloride Ep Grade 2,2,2-Trichloroethyl chloroformate 3′-Hydroxyacetophenone 5-fluoro-1,3-benzodioxole 2-Bromo-6-fluoroaniline Methyl-5-chloro-2-hdyroxy-3-nitro benzoate 5-(2,4-Difluorophenyl) isoxazole-3-carboxylicacid Methyl-5-(3-nitrophenyl)isoxazole-3-carboxylate 2-Bromo-1-(5-fluoro-2-hydroxyphenyl)ethanone Methl-4-(chlorophenyl)-2,4-dioxo butanoate 2-Morpholino nicotinicacid 5-amino-1-(2-chlorophenyl)-1H-pyrazole-4-carbonitrile ethyl 1-(6-chloropyridin-2-yl)-5-hydroxy-1H-pyrazole-4-carboxylate N-[-6,6-dimethyl-2-hepten-4-yn-1-yl]-N-(methyl-d3)-1-naphthalenemethanamine, monohydrochloride 2H-indol-2-one, 5-amino-1,3-dihydro-1-(1-methylethyl)- Nifedipine D6Related products of tetrahydrofuran
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