CC0651
Synonym(s):;Cdc34 Inhibitor, CC0651 - CAS 1319207-44-7 - Calbiochem
- CAS NO.：1319207-44-7
- Empirical Formula: C20H21Cl2NO6
- Molecular Weight: 442.29
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-03-13 23:13:44
What is CC0651?
General Description
A cell-permeable biphenylylpentanoic acid compound that acts as a selective allosteric inhibitor of E2 ubiquitin-conjugating enzyme Cdc34 (IC50 = 2.5 μM in a Sic1-SCFCdc4 assay) without affecting the activities of E1 or E3 ligases. Reported to act by trapping a weak interaction between ubiquitin and the E2 donor ubiquitin-binding site and may serve as a molecular bridge between Cdc34A and ubiquitin. Binds to Cdc34ACAT alone with an EC50 value of 267 μM, but in the presence of ubiquitin, this affinity is significantly increased (EC50 = 19 μM). Does not disrupt the interaction of Cdc34A with the RING domain of Rbx1 and is suggested to even moderately stabilize this interaction. Shown to inhibit p27Kip1 ubiquitination (IC50 = 1.72 μM) and reduce PC-3 cancer cells proliferation (~30 μM).
Please note that the molecular weight for this compound is batch-specific due to variable water content.
Biochem/physiol Actions
Cell permeable: yes
Properties of CC0651
| Boiling point: | 755.7±60.0 °C(Predicted) |
| Density | 1.410±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO: ≥ 56 mg/mL (126.61 mM) |
| form | Powder |
| pka | 3.37±0.34(Predicted) |
| color | White to off-white |
Safety information for CC0651
Computed Descriptors for CC0651
New Products
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