CAY10566

Synonym(s):2-(6-(4-(2-Chloro-5-fluorophenoxy)piperidin-1-yl)pyridazin-3-yl)-5-methyl-1,3,4-oxadiazole;Abbott compound 74;Abbott-28c;SCD1 inhibitor 28c

CAS NO.：944808-88-2
Empirical Formula: C18H17ClFN5O2
Molecular Weight: 389.81
MDL number: MFCD11976899
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-28 00:04:52

What is CAY10566?

Description

Stearoyl-CoA desaturase (SCD) catalyzes the committed step of the conversion of saturated, long-chain fatty acids to monounsaturated fatty acids. The SCD1 gene is thought to play a key role in lipid homeostasis and body weight regulation. Thus, modulating SCD1 activity pharmacologically may be a useful tool for regulating type 2 diabetes, dyslipidemia, and obesity. CAY10566 is a potent and selective inhibitor of SCD1 that demonstrates IC₅₀ values of 4.5 and 26 nM in mouse and human enzymatic assays, respectively. This compound inhibits the conversion of saturated, long-chain fatty acyl-CoAs to monounsaturated, long-chain fatty acyl-CoAs in HepG2 cells with IC₅₀ values of 7.9 and 6.8 nM, respectively, when heptadecanoic acid and palmitic acid are used as the substrate.

The Uses of CAY10566

CAY10566, is a stearoyl-CoA desaturase (SCD) inhibitor.

What are the applications of Application

CAY 10566 is Buy CAS# 944808-88-2, a potent and selective inhibitor of SCD1

Properties of CAY10566

Melting point:	160 - 170°C
Boiling point:	600.2±65.0 °C(Predicted)
Density	1.369±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO (Slightly), Methanol (Slightly)
form	Solid
pka	2.01±0.10(Predicted)
color	Pale Beige

Safety information for CAY10566

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for CAY10566

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