CAPTOPRIL DISULFIDE

Synonym(s):(2S)-1-[(2S)-3-(Acetylsulfanyl)-2-methylpropanoyl]pyrrolidine-2-carboxylic acid;N-[3-(Acetylthio)-(2S)-methylpropionyl]-L-proline;1,1′-[Dithiobis[(2S)-2-methyl-1-oxo-3,1-propanediyl]]bis-L-proline;Acetylcaptopril

CAS NO.：64806-05-9
Empirical Formula: C18H28N2O6S2
Molecular Weight: 432.55
MDL number: MFCD08063643
SAFETY DATA SHEET (SDS)
Update Date: 2026-04-21 10:31:43

What is CAPTOPRIL DISULFIDE?

Description

Captopril disulfide is a metabolite and symmetrical disulfide form of the angiotensin converting enzyme (ACE) inhibitor captopril . Captopril disulfide is the main degradation product of captopril and is formed by oxidation. It is a potential impurity in commercial preparations of captopril. Captopril disulfide inhibits angiotensin I-induced increases in mean arterial pressure in anesthetized dogs (ID₅₀ = 0.231 mg/kg, i.v.).

Chemical properties

White Solid

The Uses of CAPTOPRIL DISULFIDE

Captopril Disulfide (Captopril EP Impurity A) is a metabolite of Captopril. A new antihypertensive agent.

What are the applications of Application

Captopril Disulfide is a potent inhibitor of angiotensin-converting enzyme (ACE)

Definition

ChEBI: An organic disulfide in which the disulfide bond links two units of captopril. It is a secondary metabolite of captopril.

Properties of CAPTOPRIL DISULFIDE

Melting point:	224-226°C
Boiling point:	714.8±60.0 °C(Predicted)
Density	1.383±0.06 g/cm3(Predicted)
storage temp.	-20°C Freezer
solubility	DMSO (Slightly), Ethanol (Slightly, Sonicated), Methanol (Slightly, Sonicated)
form	neat
pka	3.29±0.20(Predicted)
form	Solid
color	White to Off-White